Pyroptosis: Gasdermin-Mediated Programmed Necrotic Cell Death.

By Jianjin Shi, Wenqing Gao, F. Shao. TIBS -Trends in Biochemical Sciences. Regular ed, 2017

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Caspase-8 induces cleavage of gasdermin D to elicit pyroptosis during Yersinia infection (2018, background): “These findings prompted the Shao group to redefined pyroptosis as cell death mediated by gasdermin activation (47).”
Neuronal Cell Death. (2018, positive): “However, active caspase-1 or caspase-11 can also cleave gasdermin D to form pores that directly permeabilize the plasma membrane (and possibly other membranes) causing necrosis (106, 290, 340, 421, 442, 622).”
Inflammasomes in neuroinflammatory and neurodegenerative diseases (2019, background): “2 of 16 EMBO Molecular Medicine 11: e10248 | 2019 ª 2019 The Authors cytosolic LPS, and the induction of pyroptosis through the cleavage of GSDMD and the release of high mobility group box 1 protein (HMGB1) and IL-1a (Lamkanfi & Dixit, 2014; Shi et al, 2017).”
Role of pyroptosis in inflammation and cancer (2022, background): “discovered that caspase-1/11/4/5 can induce pyroptosis by cleaving a protein called GSDMD to release its N-terminal domain [18, 19].”
Caspases in Cell Death, Inflammation, and Gasdermin-Induced Pyroptosis (2020, background): “However, Caspl knockout mice also do not express Casp11 (3, 75, 94).”
Structural Mechanism for GSDMD Targeting by Autoprocessed Caspases in Pyroptosis. (2020, background): “Given the death execution activity of the gasdermin family, pyroptosis is redefined as gasdermin-mediated programmed necrosis (Galluzzi et al., 2018; Shi et al., 2017).”