The basics of epithelial–mesenchymal transition (EMT): A study from a structure, dynamics, and functional perspective
By Vishal Das, Sourya Bhattacharya, Channakeshavaiah Chikkaputtaiah, Saugata Hazra, Mintu Pal. Journal of Cellular Physiology, 2019
3,873 citations recorded by the source corpus.
Epithelial–mesenchymal transition (EMT) is a key step in transdifferentiation process in solid cancer development. Forthcoming evidence suggest that the stratified program transforms polarized, immotile epithelial cells to migratory mesenchymal cells associated with enhancement of breast cancer stemness, metastasis, and drug resistance. It involves primarily several signaling pathways, such as transforming growth factor‐β (TGF‐β), cadherin, notch, plasminogen activator protein inhibitor, urokinase plasminogen activator, and WNT/beta catenin pathways. However, current understanding on the crosstalk of multisignaling pathways and assemblies of key transcription factors remain to be explored. In this review, we focus on the crosstalk of signal transduction pathways linked to the current therapeutic and drug development strategies. We have also performed the computational modeling on indepth the structure and conformational dynamic studies of regulatory proteins and analyze molecular interactions with their associate factors to understand the complicated process of EMT in breast cancer progression and metastasis. Electrostatic potential surfaces have been analyzed that help in optimization of electrostatic interactions between the protein and its ligand. Therefore, understanding the biological implications underlying the EMT process through molecular biology with biocomputation and structural biology approaches will enable the development of new therapeutic strategies to sensitize tumors to conventional therapy and suppress their metastatic phenotype.
Subfields: Molecular Biology, Oncology
View Paper: https://www.semanticscholar.org/paper/606ebb4a93b1aa4907367f11a03ce578b0f3982a
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Citations in the corpus
- The molecular mechanisms and therapeutic strategies of EMT in tumor progression and metastasis (2022, background): “During the intravasation process, MCSCs invade the surrounding stroma and disrupt endothelial junctions in order to transcend the endothelium barrier into the circulation by active or passive migration for trans-endothelial migration [171].”
- Epithelial-Mesenchymal Transition in Cancer: A Historical Overview (2020, background): “tion factors of genes that promote EMT, such as Snail, Slug, ZEB1, and Twist, to transmit EMT promotion signals [3,68].”
- The Roles of Autophagy in Cancer (2018, background): “Epithelial mesenchymal transition (EMT) is a major biological process that changes the epithelial phenotype to the mesenchymal phenotype [110].”
- Exosomes: composition, biogenesis, and mechanisms in cancer metastasis and drug resistance (2019, background): “Studies on the metastatic niche have endorsed that high amounts of integrins and MMPs increase matrix and basement membrane degradation [97].”
- Targeting cancer stem cell pathways for cancer therapy (2020, background): “Current studies hypothesize that there are five possible sources: (1) transference of fibroblasts in the host stroma; 471 (2) EMT; 472 (3) transdifferentiation of perivascular cells; 473 (4) EMT; 474 and (5) differentiation of MSCs derived from bone marrow.”
- Crosstalk between cancer-associated fibroblasts and immune cells in the tumor microenvironment: new findings and future perspectives (2021, background): “Through EMT and endothelial-to-mesenchymal transition (EndMT), most epithelial cells and endothelial cells can express a number of fibroblast markers, such as α-SMA and FAP [69, 70].”