Blimp-1 orchestrates plasma cell differentiation by extinguishing the mature B cell gene expression program.

By A. Shaffer, Kuo-I Lin, Tracy C. Kuo, Xin Yu, E. Hurt, Andreas Rosenwald, J. Giltnane, Liming Yang, Hong Zhao, K. Calame and 1 more. Immunity, 2002

1,112 citations recorded by the source corpus.

Subfields: Immunology

View Paper: https://www.semanticscholar.org/paper/1693b11a6cc110c5a6154019edd166b0b72398af

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In Immunology

Citations in the corpus

IL-21 Induces Differentiation of Human Naive and Memory B Cells into Antibody-Secreting Plasma Cells1 (2005, background): “BLIMP-1 is a transcriptional repressor that is necessary/sufficient for plasma cell differentiation in the mouse, and in human B cell lines (33, 37, 38).”
Extrafollicular antibody responses (2003, background): “Conversely, plasmablast differentiation is associated with the upregulation of Blimp-1 expression (50, 51).”
XBP1, downstream of Blimp-1, expands the secretory apparatus and other organelles, and increases protein synthesis in plasma cell differentiation. (2004, neutral): “(Shaffer et al., 2002;”
Pax5: the guardian of B cell identity and function (2007, background): “Mature B cells and plasma cells differ quite radically in their transcriptional program”
Regulation of plasma-cell development (2005, background): “), repression of genes that are required for the identity of mature and germinal-centre B cells (including genes that regulate signalling through the BCR, T-cell–B-cell interactions, CSR and somatic hypermutation) and induction of the immunoglobulin secretory programm”
Foxp3+ follicular regulatory T cells control T follicular helper cells and the germinal center response (2011, background): “31 ); Bcl-6 and Blimp-1 also mutually repress each other during B-cell differentiatio”
International Union of Basic and Clinical Pharmacology. LXXXIX. Update on the Extended Family of Chemokine Receptors and Introducing a New Nomenclature for Atypical Chemokine Receptors (2014, neutral): “CXCR5 has been detected on all peripheral blood and tonsillar B cells, but not on plasmablast and plasma cells and only on a fraction of cord blood and bone marrow B cells (Wehrli et al., 2001; Shaffer et al., 2002).”
The transcription factors Blimp-1 and IRF4 jointly control the differentiation and function of effector regulatory T cells (2011, background): “6b–d ), including known Blimp-1 target genes such as Id3 and Blimp1 itsel”
Blimp-1 promotes terminal differentiation of virus-specific CD8 T cells and represses the acquisition of central memory T cell properties (2009, background): “One such transcription factor (TF), a candidate from our microarray data and studies in B cells, is the proto-oncogene Bcl6, which is a direct target of Blimp-1 in both B and CD4 T cells (Shaffer et al., 2002; Cimmino et al., 2008).”
The endoplasmic reticulum stress response in immunity and autoimmunity (2008, background): “This de-represses BLIMP1, a zinc-finger-containing transcriptional repressor that drives plasma-cell differentiation in part by downregulating responses to BCR signalling, arresting the cell cycle, and inhibiting class switching and other germinal centre reaction”