Extrafollicular antibody responses

By I. Maclennan, K. Toellner, A. Cunningham, K. Serre, Daniel Man-yuen Sze, Elina I. Zuñiga, M. Cook, Carola G. Vinuesa. Immunological Reviews, 2003

695 citations recorded by the source corpus.

Subfields: Immunology

View Paper: https://www.semanticscholar.org/paper/52be8aaf0f6e2d02e814c2556c5e5b948dc15901

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. Jacques Banchereau
2. V. Pascual
3. C. Mackay
4. Di Yu
5. B. Moser
6. A. Cerutti
7. Carola G. Vinuesa
8. M. Smyth

Citations in the corpus

• Structure and function of the spleen (2005, background): “However, the exact anatomical position and cellular interactions that are involved in the retention of these cells are not clear (reviewed in Ref”
• Human Blood CXCR5+CD4+ T Cells Are Counterparts of T Follicular Cells and Contain Specific Subsets that Differentially Support Antibody Secretion (2011, background): “Whether human blood CXCR5+CD4+ T cells originate from cells that migrated out of GCs or Tfh cell-committed extrafollic- ular helper cells (MacLennan et al., 2003; Poholek et al., 2010) will be challenging to address in humans.”
• Translating innate immunity into immunological memory: implications for vaccine development. (2006, neutral): “The activated B cells can then (1) remain in the T cell-rich areas and differentiate into short-lived plasma cells in areas called plasma foci (Kelsoe, 2000; MacLennan et al., 2003; McHeyzer-Williams and McHeyzer-Williams, 2005) or (2) migrate into B cell follicles and, with CD4 T cell help, initiat”
• Follicular B helper T cells in antibody responses and autoimmunity (2005, background): “1a ) or the lymph-node medullary cords, where they form extrafollicular foci of short-lived plasma cells that produce low-affinity antibod”
• The regulation of IgA class switching (2008, background): “, the presence of IgA CSR in the lamina propria is in agreement with compelling evidence showing that CSR is not restricted to lymphoid follicles, but also occurs in extrafollicular lymphoid area”
• IL-21 acts directly on B cells to regulate Bcl-6 expression and germinal center responses (2010, background): “After binding protein antigen and receiving cognate help from T cells, B cells can differentiate along the extrafollicular pathway, generating short-lived plasma cells that produce low affinity antibodies, or can enter the follicles and give rise to GCs (MacLennan et al., 2003).”
• Follicular Helper T Cells. (2016, background): “This occurs through the antigen-specific Tfh-mediated selection of GC B cells, which enables them to undergo further rounds of division and SHM (25).”
• The transcriptional repressor Bcl-6 directs T follicular helper cell lineage commitment. (2009, background): “B cell switching toaberrant isotypes in the contextofGCreactions poses a greater threat than during extrafollicular responses because the latter produce comparably low-affinity antibodies (MacLennan et al., 2003), and also the offspring of GC B cells may live for decades in an individual.”