XBP1, downstream of Blimp-1, expands the secretory apparatus and other organelles, and increases protein synthesis in plasma cell differentiation.

By A. Shaffer, Miriam Shapiro-Shelef, N. Iwakoshi, Ann-Hwee Lee, Shu‐Bing Qian, Hong Zhao, Xin Yu, Liming Yang, Bruce K. Tan, Andreas Rosenwald and 7 more. Immunity, 2004

1,064 citations recorded by the source corpus.

Subfields: Cell Biology, Immunology

View Paper: https://www.semanticscholar.org/paper/c661cb8b23f3f83c98ed84feff2b01a9d7e664cc

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cell Biology

1. R. Kaufman
2. H. Chae
3. Hyung-Ryong Kim
4. Jun Wu
5. Peter Walter
6. R. Yadav
7. H. Rashid
8. Jonathan H. Lin

In Immunology

1. R. Dalla-Favera
2. R. Kaufman
3. U. Klein

Citations in the corpus

• Germinal centres: role in B-cell physiology and malignancy (2008, background): “BLIMP1 was subsequently shown to act upstream of X-box binding protein 1 (XBP1), a transcription factor that is required for the secretory phenotype of plasma cell”
• ER stress: Autophagy induction, inhibition and selection (2015, background): “The encoded XBP1 protein subsequently translocates to the nucleus where it acts as a potent transcription factor by binding to UPR elements and activating a broad spectrum of UPR-related genes involved in ER membrane biogenesis, ER protein folding, physical expansion of the ER, ERAD, protein entry i”
• Endoplasmic reticulum stress in disease pathogenesis. (2008, background): “Plasma cells may employ cell-type-specific mechanisms, such as the transcription factor Blimp-1 (5), to specifically use distinct UPR signaling pathways during their development.”
• Autophagy Counterbalances Endoplasmic Reticulum Expansion during the Unfolded Protein Response (2006, background): “The transcription factor XBP1, the metozoan ortholog of Hac1, was shown in mammalian cells to induce an expansion of the ER [67,68].”