AU-rich-element-mediated upregulation of translation by FXR1 and Argonaute 2.

By Shobha Vasudevan, J. Steitz. Cell, 2007

691 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/16605b150813d2ce8e3b68166edde8c097f700cb

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

Citations in the corpus

The many pathways of RNA degradation. (2009, background): “768 Cell 136, 763–776, February 20, 2009 ª2009 Elsevier Inc. are the AU-rich elements (AREs), which are bound by a number of proteins to either extend or shorten mRNA life span, often in response to extracellular signals (see, for example, Vasudevan and Steitz, 2007).”
Overview of MicroRNA Biogenesis, Mechanisms of Actions, and Circulation (2018, background): “Several miRNAs, including let7, were found to be associated with AGO2 and FXR1 to activate translation during cell cycle arrest, but they inhibit translation in proliferating cells (55).”
Mechanisms of miRNA-Mediated Gene Regulation from Common Downregulation to mRNA-Specific Upregulation (2014, background): “The mRNA expression could be activated by the direct action of miRNPs and/or could be indirectly relieved from miRNA-mediated repression by abrogating the action of repressive miRNPs [82].”
Regulation of mRNA translation and stability by microRNAs. (2010, background): “Vasudevan and coworkers (11, 131) found that miRNAs repress translation in proliferating cells but upregulate it in quiescent cells arrested in G0/G1.”
MicroRNA-10a binds the 5'UTR of ribosomal protein mRNAs and enhances their translation. (2008, background): “…general significance is supported by recent data demonstrating that AGO2-containing complexes are involved in translational activation during serum starvation (Vasudevan and Steitz, 2007) and that some miRNAs can induce translation of target mRNAs during cell-cycle arrest (Vasudevan et al., 2007).”
Persistent DNA damage signaling triggers senescence-associated inflammatory cytokine secretion (2009, neutral): “The results suggest that the co-localization of AGO2 and GW182 foci with MVBs defines subcellular structures that are distinct from P-bodies, as proposed previousl”
Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight? (2008, result): “Cosedimentation of a significant fraction of cellular miRNAs or AGO proteins with polysomes has also been reported in other studie”