The glutamate homeostasis hypothesis of addiction

By Peter W. Kalivas. Nature Reviews Neuroscience, 2009

1,328 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Cognitive Neuroscience

View Paper: https://www.semanticscholar.org/paper/926519bbbfc2dba348202b61755ab1bafbd520ae

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cellular and Molecular Neuroscience

In Cognitive Neuroscience

Citations in the corpus

The Cystine/Glutamate Antiporter System xc − in Health and Disease: From Molecular Mechanisms to Novel Therapeutic Opportunities (2013, positive): “Thus, increasing cystine/glutamate exchange via system xc elevates basal levels of extracellular extrasynaptic glutamate that, in turn, stimulate presynaptic mGluR2/3 (188), and stimulating mGluR2/3 decreases synaptic glutamate release probability in prefrontal projections into the accumbens (107, 1”
Projection-specific modulation of dopamine neuron synapses by aversive and rewarding stimuli (2011, neutral): “…to the delayed yet persistent synaptic adaptations observed at excitatory synapses in the NAc (Kauer and Malenka, 2007; Conrad et al., 2008; Kalivas, 2009; Chen et al., 2010; Wolf, 2010), changes that are dependent on the initial synaptic adaptations in midbrain DA neurons (Mameli et al.,…”
Addiction: Beyond dopamine reward circuitry (2011, background): “Corticostriatal glutamatergic terminals are responsible for learning well-established behaviors and for changing these behaviors when they are no longer adaptive, and neuroadaptations in these projections (and in amygdalostriatal glutamate pathways) with repeated drug use (including impaired regulat”
Neurobiology of the incubation of drug craving (2011, positive): “Consequently, when cocaine-associated cues are presented after prolonged drug withdrawal, and glutamate is released in the NAc [95, 96], local NAc neurons would respond more robustly, leading to enhanced cocaine seeking (i.”
Towards a glutamate hypothesis of depression (2011, background): “A framework shift of this kind has already occurred for schizophrenia and addiction (Kalivas, 2009; Kantrowitz and Javitt, 2010).”
Transcriptional and Epigenetic Mechanisms of Addiction (2011, background): “, ΔFOSB mediates the structural plasticity that is induced in NAc by cocain”
Neuroanatomical and Neurochemical Substrates of Timing (2011, neutral): “…16 REVIEW .............................................................................................................................................. Neuropsychopharmacology REVIEWS 2006; Kalivas, 2009; Williamson et al, 2008).”
Metabotropic glutamate receptors: From the workbench to the bedside (2010, background): “An elegant series of experiments by Peter Kalivas and his associates has linked a defective activation of mGlu2/3 receptors to abnormalities of synaptic plasticity in the core of nucleus accumbens underlying the enduring vulnerability to drug reinstatement in addiction (reviewed by Kalivas, 2009).”