Skeletal remodeling in health and disease

By M. Zaidi. Nature Medicine, 2007

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Lrp5 controls bone formation by inhibiting serotonin synthesis in the duodenum: an entero-bone endocrine axis (2008, background): “Over the last 15 years, molecular and genetic studies have identified numerous local and systemic regulators of this process and as a result have considerably improved our molecular understanding of both aspects of bone remodeling (Zaidi, 2007).”
TGF-β1-induced Migration of Bone Mesenchymal Stem Cells Couples Bone Resorption and Formation (2009, neutral): “This bone remodeling process is accomplished by a precise coordination of the activities of two cell types: osteoblasts, which deposit the calcified bone matrix, and osteoclasts, which resorb bone2,3.”
Inflammatory bone loss: pathogenesis and therapeutic intervention (2012, background): “Overall, RUNX2 appears to orchestrate multiple osteoblastogenic signals and thus also amplifies its own gene activation and transcriptional activit”
Osteoblast-Osteoclast Interactions (2017, background): “Bone metabolism diseases, such as osteoporosis or osteopetrosis will occur (3).”
Current Understanding of RANK Signaling in Osteoclast Differentiation and Maturation (2017, background): “The mature skeleton is maintained by bone remodeling, which is a dynamic process in which the bone is first resorbed by osteoclasts, followed by bone formation in the lacunae by osteoblasts (Zaidi, 2007).”