Leptin regulation of bone resorption by the sympathetic nervous system and CART

By Florent Elefteriou, J. Ahn, S. Takeda, M. Starbuck, Xiangli Yang, Xiuyun Liu, H. Kondo, W. Richards, Tony W. Bannon, M. Noda and 3 more. Nature, 2005

1,297 citations recorded by the source corpus.

Subfields: Endocrine and Autonomic Systems, Epidemiology, Physiology

View Paper: https://www.semanticscholar.org/paper/b15e223d490458f11b217b7b1b4033102084ed5c

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Citations in the corpus

Mechanisms of Disease: is osteoporosis the obesity of bone? (2006, background): “Recent data demonstrate that enhanced sympathetic activity also promotes bone resorption”
From space to Earth: advances in human physiology from 20 years of bed rest studies (1986–2006) (2007, background): “There is anecdotal evidence that, despite the fact that b2adrenergic transmission seems to enhance osteoclastic activity (Elefteriou et al. 2005), systemic administration of b2-agonsists has surprisingly been reported to reduce disuse-related bone losses (Bloomfield et al. 1997).”
Building strong bones: molecular regulation of the osteoblast lineage (2011, background): “First, it directly regulates the expression of the osteoblast-derived molecules osteocalcin (a bone matrix protein with newly reported roles in glucose homeostasis and male fertility ( Box 1 )) and receptor activator of nuclear factor-κB ligand (RANKL; also known as TNFSF11), which promotes osteocla”
The Human Obesity Gene Map: The 2005 Update (2006, background): “2 CART Cocaine- and amphetamine-regulated transcript Increased susceptibility to diet-induced obesity (319,320)”
Skeletal remodeling in health and disease (2007, background): “Consistent with this, mice lacking the leptinergic signals that regulate body mass, namely α-melanocyte stimulating hormone or cocaine- and amphetamine-regulated transcript (CART), did not show a bone-related phenotyp”
Physiology of leptin: energy homeostasis, neuroendocrine function and metabolism. (2015, background): “Sympathetic activation inhibits bone formation and increases bone resorption mediated by β2 adrenergic receptors in osteoblasts [130, 131].”
Leptin regulation of bone mass, appetite and energy expenditure relies on its ability to inhibit serotonin synthesis in the brainstem (2009, neutral): “One mediator linking leptin signaling in the brain to bone remodeling is the sympathetic tone which inhibits bone formation and favors bone resorption through the b2 adrenergic receptor (Adrb2) expressed in osteoblasts (Elefteriou et al., 2005; Takeda et al., 2002).”
The integrated stress response (2016, neutral): “Phosphorylation of ATF4 at S245 by ribosomal protein S6 kinase a -2 (RSK2) or S254 by protein kinase A (PKA) can enhance its transcriptional activity during osteoblast and osteoclast differentiation [107,159].”