Endogenous human microRNAs that suppress breast cancer metastasis

By S. Tavazoie, Claudio R. Alarcón, Thordur Oskarsson, David Padua, Qiongqing Wang, Paula D. Bos, W. Gerald, J. Massagué. Nature, 2008

1,907 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/154a86c607a01cac2c10128f461ec7f7c925d1cf

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Citations in the corpus

Lost in translation: an assessment and perspective for computational microRNA target identification (2009, background): “Each miRNA is 19–24 nucleotides in length and is processed from a longer transcript, referred to as the primary transcript (pri-miRNA), which can be up to thousands of nucleotides long.”
AACR Centennial Series: The Biology of Cancer Metastasis: Historical Perspective (2010, positive): “2008 Joan Massagué and coworkers reported that micro-RNAs can suppress metastases (236).”
Thresholds for therapies: highlights of the St Gallen International Expert Consensus on the Primary Therapy of Early Breast Cancer 2009 (2009, background): “Reintroduction of specific microRNAs has proved to be effective in suppressing metastases in animal models [13].”
A Pleiotropically Acting microRNA, miR-31, Inhibits Breast Cancer Metastasis (2009, positive): “…that function as classical oncogenes or tumor suppressor genes (Ventura and Jacks, 2009), as well as a limited number that act at late stages of tumor progression (Ma et al., 2007; Tavazoie et al., 2008; Huang et al., 2008; Asan- gani et al., 2008; Zhu et al., 2008; Lujambio et al., 2008).”
STAT3 activation of miR-21 and miR-181b-1, via PTEN and CYLD, are part of the epigenetic switch linking inflammation to cancer (2010, background): “This tumor-suppressor role of miR-335 during the early stages of tumorigenesis is unexpected, as this microRNA was previously characterized as being downregulated in metastatic tumors (Tavazoie et al., 2008).”
Dynamic interplay between the collagen scaffold and tumor evolution (2010, background): “Analysis of human tumors has revealed an association between collagen expression or collagen modifying enzymes and poor prognosis [16,17,27,28,57], supporting the notion that collagen remodeling is highly relevant to human cancer progression.”
An Endothelial-specific microRNA Governs Vascular Integrity and Angiogenesis (2008, background): “inhibit tumorigenesis and to be downregulated in metastatic breast tumors, although the specific cell type in which it was downregulated and the targets of miR-126 that might mediate these actions were not defined (Tavazoie et al., 2008).”
MicroRNA control in the immune system: basic principles. (2009, background): “…9, 2009 ©2009 Elsevier Inc. 33 process, including tumor metastasis and cancer stem cell maintenance (Huang et al., 2008; Kent and Mendell, 2006; Ma et al., 2007; Tavazoie et al., 2008; Yu et al., 2007). miRNAs appear also to be heavily involved in the pathogenesis of leukemias and lymphomas.”
A reciprocal repression between ZEB1 and members of the miR-200 family promotes EMT and invasion in cancer cells (2008, background): “EMBO open A reciprocal repression between ZEB1 and members of the miR-200 family promotes EMT and invasion in cancer cells”
MicroRNAs and cancer: short RNAs go a long way. (2009, background): “Based on their differential expression in nonmetastatic versus metastatic breast cancer cell lines, miR-126, miR-206, and miR-335 were also proposed to be inhibitors of tumor progression (Tavazoie et al., 2008).”
Genomic profiling of microRNA and mRNA reveals deregulated microRNA expression in prostate cancer (2008, background): “miR-1 is a homologue of miR-206 , which is a suppressor of metastasis in breast cancer (34).”