Mitochondrial Biogenesis in Mammals: The Role of Endogenous Nitric Oxide

By E. Nisoli, E. Clementi, C. Paolucci, Valeria Cozzi, C. Tonello, C. Sciorati, R. Bracale, A. Valerio, M. Francolini, S. Moncada and 1 more. Science, 2003

1,273 citations recorded by the source corpus.

Subfields: Epidemiology, Molecular Biology, Physiology

View Paper: https://www.semanticscholar.org/paper/14f02c3c195955e62c949d422ed1c9dbcfdb81f0

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Citations in the corpus

PGC-1 coactivators: inducible regulators of energy metabolism in health and disease. (2006, background): “More recently, NO was shown to activate mitochondrial biogenesis coincident with increased PGC-1α expression in a variety of cell types, including adipocytes and HeLa cells (47).”
Peroxisome proliferator-activated receptor gamma coactivator 1 coactivators, energy homeostasis, and metabolism. (2006, background): “Interestingly, nitric oxide increases PGC-1 levels and mitochondrial biogenesis via cGMPdependent pathways (39).”
Transcriptional paradigms in mammalian mitochondrial biogenesis and function. (2008, background): “Interestingly, tissue mitochondria in mice with a homozygous disruption of the gene encoding endothelial NO synthase (eNOS / ) were somewhat smaller and less densely packed than in wild-type mice (150, 151).”
Cellular Stress Responses, The Hormesis Paradigm, and Vitagenes: Novel Targets for Therapeutic Intervention in Neurodegenerative Disorders (2010, neutral): “…by CO has become an emerging area and mitochondrial ROS are now implicated in various cellular regulatory processes, including cell proliferation, expression of angiogenesis factor, metallo-proteinase mitochondrial biogenesis (328), and stabilization of hypoxia-inducible factor-1 (HIF-1).”
Regulatory role for the arginine-nitric oxide pathway in metabolism of energy substrates. (2006, background): “species; SREBP, sterol regulatory element binding proteins; Viagra, sildenafil cit activated receptor-g coactivator 1a up-regulates the expression of these transcription factors and UCPs in a cGMPdependent mechanism [52].”
Transcriptional control of mitochondrial biogenesis: the central role of PGC-1alpha. (2008, background): “Tissues of eNOS mice such as the brain, liver, muscle and heart have a slightly decreased content of some mitochondrial proteins.(47) However, oxidative capacity and mitochondrial enzymes are not altered in hearts of eNOS mice, suggesting that eNOS is not involved in cardiac basal mitochondrial biog”
Regulation of mitochondrial biogenesis (2010, background): “HeLA cells expressing eNOS (endothelial NO synthase) display an increase in mtDNA content, cytochrome c and COX IV protein expression levels, as well as PGC-1α, NRF-1 and Tfam mRNA expression [26].”
Transcriptional control of mitochondrial biogenesis and function. (2009, background): “Another signal that impacts mitochondrial biogenesis is the gas nitric oxide (NO), which induces PGC-1α expression via a cGMP-dependent mechanism (166).”
The physiology and pathophysiology of nitric oxide in the brain. (2005, background): “Therefore, mice lacking functional eNOS show a lower number of mitochondria (Nisoli et al., 2003), and mice overexpressing PGC-1alfa have a larger number of mitochondria in cardiac and skeletal muscles (Lin et al., 2002).”
The discovery of nitric oxide and its role in vascular biology (2006, background): “…in which we are revealing links between cell bioenergetics and signalling mechanisms is the observation that NO plays a role in mitochondriogenesis (Nisoli et al., 2003), an additional indication that NO might be involved in the regulation of the balance between glycolysis and oxidative…”
Mitochondrial biogenesis and mitochondrial DNA maintenance of mammalian cells under oxidative stress. (2005, background): “…stress Recently, it was reported that elevated levels of nitric oxide (NO) stimulate mitochondrial biogenesis by upregulation of the expression of PGC-1 through a soluble guanylate cyclase-sensitive, cGMP-dependent signaling pathway in a number of unrelated cell lines (Nisoli et al., 2003).”
Transcriptional regulatory circuits controlling mitochondrial biogenesis and function. (2004, background): “More recently, evidence has emerged that nitric oxide (NO) activates mitochondrial biogenesis in a variety of cell types including adipocytes, and HeLa cells (Nisoli et al. 2003).”
Mitochondrial Dysfunction in Diabetes: From Molecular Mechanisms to Functional Significance and Therapeutic Opportunities (2010, positive): “Conversely, smaller and prolonged increases in NO induce mitochondrial biogenesis, as observed in several cell types (239).”