Eukaryotic stress granules are cleared by autophagy and Cdc48/VCP function.

By J. Buchan, Regina-Maria Kolaitis, J. Paul Taylor, R. Parker. Cell, 2013

718 citations recorded by the source corpus.

Subfields: Genetics, Molecular Biology, Neurology

View Paper: https://www.semanticscholar.org/paper/147c511585915d2e7fd89053162370ebc485dbd5

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Citations in the corpus

A census of human RNA-binding proteins (2014, background): “of these RNA-protein granules leads to cellular stress predominantly affecting neuronal cells (Buchan et al., 2013; Li et al., 2013; Liu-Yesucevitz et al., 2011; Ramaswami et al., 2013).”
Principles and Properties of Stress granules (2016, background): “The key observation is that inhibition of VCP/Cdc48 function in yeast or mammals leads to the accumulation of stress granules in the cytosol, as well as a reduction in stress granules that can be trapped in intravacuolar vesicles [13].”
Exome sequencing in amyotrophic lateral sclerosis identifies risk genes and pathways (2015, positive): “VCP and autophagy are required for the removal of stress granules, dense cytoplasmic protein/RNA aggregates which are a common feature of ALS pathology (36).”
G3BP1 is a tunable switch that triggers phase separation to assemble stress granules (2020, neutral): “Indeed, depletion or knockout of many individual RBPs that are capable of LLPS in vitro has no apparent impact on assembly of the RNP granule to which they belong (Buchan et al., 2013).”
Liquid-Liquid Phase Separation in Disease. (2019, background): “, VCP and UBQLN2 (7, 29, 39), compose another class.”
Distinct stages in stress granule assembly and disassembly (2016, background): “…of granule cores may reflect the requirement of a myriad of ATP-dependent remodeling complexes (e.g. heat shock 70 or p97/VCP AAA-ATPase complexes [Buchan et al., 2013; Walters et al., 2015]) and could serve as a cytoprotective mechanism to acutely re-nucleate stress granules if the cell…”
Interactions between autophagy receptors and ubiquitin-like proteins form the molecular basis for selective autophagy. (2014, background): “Cdc48 is the likely candidate selective autophagy receptor, as it is required for autophagic clearance of ubiquitinated Cdc13, a critical regulator of telomere maintenance (Baek et al., 2012), as well as mRNPs during granulophagy (Buchan et al., 2013).”
Autophagy-Dependent Ferroptosis: Machinery and Regulation (2020, neutral): “, 2015), stress granules (granulophagy) (Buchan et al., 2013), proteasomes (proteaphagy) (Marshall et al.”
Context-Dependent and Disease-Specific Diversity in Protein Interactions within Stress Granules (2018, background): “5% (361/14,352) of all proteins in the PPI dataset (Figure 3H), suggesting that tight surveillance of SG proteins through interactions with ATG8 proteins may facilitate the important role of autophagy in SG clearance (Buchan et al., 2013).”
The stress granule transcriptome reveals principles of mRNA accumulation in stress granules (2017, neutral): “…SG clearance are implicated in degenerative diseases such as amyotrophic lateral sclerosis (ALS) and multisystem proteinopathy, where aberrant SG-like assemblies form (Buchan et al., 2013; Dewey et al., 2012; Kim et al., 2013b; Li et al., 2013; Mackenzie et al., 2017; Ramaswami et al., 2013).”
Phase separation by low complexity domains promotes stress granule assembly and drives pathological fibrillization (2015, neutral): “ALS, FTD, and myopathy are also caused by mutations in VCP/p97, which are associated with impaired autophagic clearance of stress granules (Buchan et al., 2013).”