Principles and Properties of Stress granules

By David S. W. Protter, R. Parker. Trends in Cell Biology, 2016

1,524 citations recorded by the source corpus.

Stress granules are assemblies of untranslating mRNPs that form from mRNAs stalled in translation initiation. Stress granules form through interactions between mRNA binding proteins that link together populations of mRNPs. Interactions promoting stress granule formation include conventional protein-protein interactions, as well as interactions involving intrinsically disordered regions of proteins. Assembly and disassembly of stress granules are modulated by a variety of post-translational modifications as well as a number of ATP dependent RNP or protein remodeling complexes, illustrating that stress granules represent an active liquid wherein energy input maintains their dynamic state. Stress granule formation modulates the stress response, viral infection, and signaling pathways. Persistent or aberrant stress granule formation contributes to neurodegenerative disease and some cancers.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/558e2eb085e67d31ddd8dfe911642be41d777083

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In Molecular Biology

Citations in the corpus

Molecular Mechanisms of TDP-43 Misfolding and Pathology in Amyotrophic Lateral Sclerosis (2019, background): “The phase separation behavior of the RNA binding proteins, seems closely associated with their propensity to form stress granules (Molliex et al., 2015; Protter and Parker, 2016; Riback et al., 2017).”
The stress granule transcriptome reveals principles of mRNA accumulation in stress granules (2017, positive): “Stress granules (SGs) are non-membrane-bound assemblies of RNA and protein that form when translation initiation is limited (Protter and Parker, 2016; Buchan and Parker, 2009).”
Liquid phase condensation in cell physiology and disease (2017, background): “F. Wippich et al., Dual specificity kinase DYRK3 couples stress granule condensation/dissolution to mTORC1 signaling.”
Role of pyroptosis in inflammation and cancer (2022, background): “One study revealed that the formation of stress granules induced by sodium arsenite specifically inhibited the activation of the NLRP3 inflammasome [89].”
A molecular grammar governing the driving forces for phase separation of prion-like RNA binding proteins (2018, neutral): “, 2016), a coupling of folded oligomerizing domains and disordered regions (Feric et al., 2016; Protter and Parker, 2016), or coiled-coil proteins (Woodruff et al.”
Overview of MicroRNA Biogenesis, Mechanisms of Actions, and Circulation (2018, background): “SG are known to act as intermediate storage of messenger ribonucleoproteins (mRNPs) that have stalled during translation or following viral infection (112).”
LNCcation: lncRNA localization and function (2021, background): “This and subsequent studies revealed that the majority of mitochondrially enriched lncRNAs play key roles in mitochondrial gene regulation (Mercer et al., 2011; Rackham et al., 2012; Rackham et al., 2011).”
Competing protein-RNA interaction networks control multiphase intracellular organization (2020, positive): “specificity, as they feature multiphase structure, are not required for cell viability, form in a controllable manner, and have known composition (Ivanov et al., 2019; Protter and Parker, 2016; Youn et al., 2019).”