Role of brain insulin receptor in control of body weight and reproduction.

By Jens C. Brüning, D. Gautam, D. Burks, J. Gillette, M. Schubert, P. Orban, R. Klein, W. Krone, D. Müller-Wieland, C. Kahn. Science, 2006

1,070 citations recorded by the source corpus.

Subfields: Endocrine and Autonomic Systems, Endocrinology, Diabetes and Metabolism, Surgery

View Paper: https://www.semanticscholar.org/paper/1314b211e0423869e421990a14eb0e64c9fa71e7

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Endocrine and Autonomic Systems

1. Roger Cone
2. P. Havel
3. B. Kahn
4. Liangyou Rui
5. H. Fang
6. R. L. Judd
7. D. Hardie
8. Haiming Cao

In Endocrinology, Diabetes and Metabolism

1. P. Havel
2. I. Torres-Alemán
3. J. Silva
4. Bruce S. McEwen

In Surgery

1. P. Havel
2. B. Kahn
3. C. R. Kahn
4. G. Dienel
5. Liangyou Rui
6. H. Fang
7. R. L. Judd
8. D. Hardie

Citations in the corpus

• Insulin Action in Brain Regulates Systemic Metabolism and Brain Function (2014, background): “The best evidence that insulin in the brain has a direct effect on reproductive function comes from NIRKO mice, in which both sexes display hypothalamic hypogonadism, with reduced fertility due to hypothalamic dysregulation of luteinizing hormone, which can be corrected by the injection of gonadotro”
• From mice to men: insights into the insulin resistance syndromes. (2006, background): “NIRKO mice of both sexes have a decrease in fertility due to hypothalamic hypogonadism (27).”
• Sugar for the brain: the role of glucose in physiological and pathological brain function (2013, background): “Furthermore, brain insulin receptors [56] and other metabolic receptors and transporters, such as glucose transporters [57, 58], mediate metabolic signaling in the brain.”
• Anatomy and regulation of the central melanocortin system (2005, background): “A mouse strain with a brain-specific insulin receptor knockout shows a mild obesity syndrom”
• Thermogenic mechanisms and their hormonal regulation. (2006, background): “Expectedly, these mice have increased food intake and are more susceptible to diet-induced obesity, but they also show central depression of reproductive function (46).”
• Decreasing hypothalamic insulin receptors causes hyperphagia and insulin resistance in rats (2002, background): “Recent loss-of-function studies have provided strong support for a physiological role of brain insulin receptors in the long-term modulation of energy balance, showing that neuron-specific disruption of the insulin receptor (IR) gene throughout the central nervous system leads to increases in body f”
• Hypothalamic insulin signaling is required for inhibition of glucose production (2002, background): “It is noteworthy that prolonged or chronic impairment of CNS insulin signaling also leads to hyperphagia, increased plasma insulin levels and decreased insulin sensitivit”