Hypothalamic insulin signaling is required for inhibition of glucose production
By S. Obici, Bei B. Zhang, G. Karkanias, L. Rossetti. Nature Medicine, 2002
919 citations recorded by the source corpus.
Subfields: Endocrine and Autonomic Systems, Nutrition and Dietetics, Surgery
View Paper: https://www.semanticscholar.org/paper/68b6e17841fe679212a004511fe3bd2a48a8141f
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In Endocrine and Autonomic Systems
In Nutrition and Dietetics
In Surgery
Citations in the corpus
- Impaired regulation of hepatic glucose production in mice lacking the forkhead transcription factor Foxo1 in liver. (2007, background): “HGP is a complex process and is regulated both directly and indirectly (Obici et al., 2002) via transcriptional and posttranscriptional mechanism, in response to hormones, nutrients, and other cues.”
- Hepatic Acetyl CoA Links Adipose Tissue Inflammation to Hepatic Insulin Resistance and Type 2 Diabetes (2015, neutral): “…to direct actions of insulin on liver (Edgerton et al., 2009; Hepp, 1977; Pilkis and Granner, 1992) and indirect effects of insulin on brain (Hill et al., 2010; Jordan et al., 2010; Lin et al., 2010; Obici et al., 2002; Schwartz et al., 2013) and adipocyte (Lewis et al., 1996; Rebrin et al., 1996).”
- Insulin Action in Brain Regulates Systemic Metabolism and Brain Function (2014, background): “Conversely, CNS injection of insulin increases hepatic insulin sensitivity, and this occurs through central pathways involving PI3K and ATP-dependent potassium channels (66).”
- A ceramide-centric view of insulin resistance. (2012, background): “Ceramides and the Brain Recent findings from numerous groups have established an essential role for hypothalamic insulin signaling in the maintenance of glucose tolerance (Gelling et al., 2006; Myers et al., 2009; Obici et al., 2002).”
- Anatomy and regulation of the central melanocortin system (2005, background): “, arguing for a physiological role for central insulin action in energy homeostasis, and as described below, central insulin signaling also seems to be important for the regulation of glucose production by the live”
- Adiponectin Regulation and Function (2018, positive): “Thus, adiponectin’s ability to activate hypothalamic insulin signaling pathways is an important neuroendocrine mechanism that regulates hepatic insulin resistance and hepatic glucose production (211, 220).”
- Energy Metabolism in the Liver (2014, positive): “Insulin has been reported to activate its receptors in hypothalamic neurons and suppress HGP in a vagus nerve output-dependent manner (194, 196).”