Decreasing hypothalamic insulin receptors causes hyperphagia and insulin resistance in rats

By S. Obici, Zhaohui Feng, G. Karkanias, D. Baskin, L. Rossetti. Nature Neuroscience, 2002

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From the Triumvirate to the Ominous Octet: A New Paradigm for the Treatment of Type 2 Diabetes Mellitus (2009, background): “(239,240) in rodents have also provided evidence for cerebral insulin resistance leading to increased HGP and reduced muscle glucose uptake.”
Mechanisms of obesity-associated insulin resistance: many choices on the menu. (2007, background): “Central infusion of oleic acid potently increases hepatic insulin sensitivity in rats (Obici et al. 2002b), and similar effects were noted after central infusion of an inhibitor of carnitine palmitoyltransferase-1 (CPT-1) (Obici et al. 2003), which increases hypothalamic fatty acyl-CoA by reducing…”
Protein tyrosine phosphatase 1B inhibitors for diabetes (2002, background): “PTP1B in diabetes and obesity Insulin resistance is evident in many tissues that are important for GLUCOSE HOMEOSTASIS , including muscle, liver and — more recently — in fat and at the level of the central nervous system (CN”
Energy Metabolism in the Liver (2014, neutral): “rons and suppress HGP in a vagus nerve output-dependent manner (194, 196).”
From mice to men: insights into the insulin resistance syndromes. (2006, background): “HIRKD mice show an increase in expression of the orexigenic peptides neuropeptide Y (NPY) and Agouti-related peptide (AgRP), a 50% increase in food intake, and a fourfold increase in subcutaneous fat, but curiously no significant increase in visceral adiposity (29).”