Sugar for the brain: the role of glucose in physiological and pathological brain function
By P. Mergenthaler, U. Lindauer, G. Dienel, A. Meisel. Trends in Neurosciences, 2013
1,467 citations recorded by the source corpus.
The mammalian brain depends upon glucose as its main source of energy, and tight regulation of glucose metabolism is critical for brain physiology. Consistent with its critical role for physiological brain function, disruption of normal glucose metabolism as well as its interdependence with cell death pathways forms the pathophysiological basis for many brain disorders. Here, we review recent advances in understanding how glucose metabolism sustains basic brain physiology. We aim at synthesizing these findings to form a comprehensive picture of the cooperation required between different systems and cell types, and the specific breakdowns in this cooperation which lead to disease.
Subfields: Endocrinology, Diabetes and Metabolism, Physiology, Surgery
View Paper: https://www.semanticscholar.org/paper/57779e8a2996dbb5c15ba77f441f229a3d482866
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Citations in the corpus
- GLUCOSE: GeneraLized and COntextualized Story Explanations (2020, background): “Human brain functions such as thinking, memory, and learning are closely linked to the glucose levels and how efficiently the brain uses this fuel source (Mergenthaler et al., 2013).”