From mice to men: insights into the insulin resistance syndromes.

By Sudha B. Biddinger, C. R. Kahn. Annual Review of Physiology, 2006

751 citations recorded by the source corpus.

Subfields: Epidemiology, Molecular Biology, Physiology

View Paper: https://www.semanticscholar.org/paper/45a33fce9ecc8b8e176981cdfb9242079b2dbb67

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Citations in the corpus

Inflammation, Defective Insulin Signaling, and Mitochondrial Dysfunction as Common Molecular Denominators Connecting Type 2 Diabetes to Alzheimer Disease (2014, background): “Knowledge of the molecular mechanism(s) of defective insulin signaling has increased tremendously during the past decades (24,25).”
Cellular and Molecular Players in Adipose Tissue Inflammation in the Development of Obesity-induced Insulin Resistance (2013, positive): “Insulin resistance is the condition where the body does not respond appropriately to circulating insulin [1,2].”
SIRT3 Deficiency and Mitochondrial Protein Hyperacetylation Accelerate the Development of the Metabolic Syndrome (2011, positive): “Insulin resistance is a hallmark of obesity and the metabolic syndrome (Biddinger and Kahn, 2006; Kahn et al., 2006; Reaven, 1988).”
How increased oxidative stress promotes longevity and metabolic health: The concept of mitochondrial hormesis (mitohormesis). (2010, background): “Hence it appears generally accepted that insulin resistance causes type 2 diabetes leading to reduced intracellular glucose availability (Biddinger and Kahn, 2006).”
Hepatocellular carcinoma in non-alcoholic fatty liver disease: an emerging menace. (2012, background): “Both are common features of NAFLD and have been linked to tumor development [85,86].”
Mechanisms of diabetic complications. (2013, background): “The mechanisms thought to be important for the development of insulin resistance are not further discussed within this review; however, they have been elegantly reviewed previously (43, 141).”
The world of protein acetylation. (2016, background): “ripheral tissues, decreases glucose production and stimulates glycogen synthesis in the liver [352,353].”
Selective versus total insulin resistance: a pathogenic paradox. (2008, background): “To answer this question, Kahn and associates have conducted systematic studies in mice in which they have ablated the insulin receptor gene in each of these suspect organs (Biddinger and Kahn, 2006).”
Regulation of insulin sensitivity by serine/threonine phosphorylation of insulin receptor substrate proteins IRS1 and IRS2 (2012, background): “It also underlies risk factors—including hyperglycaemia, dyslipidaemia and hypertension—for the clustering of type 2 diabetes with cardiovascular disease, non-alcoholic fatty liver disease and related maladies (metabolic syndrome) [2].”