Regulation of Th2 differentiation and Il4 locus accessibility.

By K. M. Ansel, I. Djuretic, Bogdan Tanasa, Anjana Rao. Annual Review of Immunology, 2006

705 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/12e96c397e389b1ee470e6e36e992f5008d7b196

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Citations in the corpus

Fish Cytokines and Immune Response (2012, background): “The IL-4 gene is conserved evolutionally in the animal kingdom and has been isolated from various animals including humans [149], mice [150, 151] and bovines [152], in which the IL-4 locus has been mapped in a region adjacent to those of IL-5 and IL-13 on the same chromosome [153, 154].”
Phenotypic and functional specialization of FOXP3+ regulatory T cells (2011, background): “Production of these polarizing cytokines is dictated by the type of pathogen encountered, such that: TGFβ and IL-6 direct the development of IL-17-producing T H 17 cells during extracellular bacterial or fungal infection; IFNγ and IL-12 drive the differentiation of IFNγ-producing T H 1 cells that he”
DNA methylation profiling of human chromosomes 6, 20 and 22 (2006, background): “For instance, comparative analysis of the mouse IL4 locus identified two ECRs that undergo differential methylation during differentiation from naive CD4 to T H 1 and T H 2 cells and can act as enhancers for IL4 expression (reviewed in ref”
Global mapping of H3K4me3 and H3K27me3 reveals specificity and plasticity in lineage fate determination of differentiating CD4+ T cells. (2009, background): “…have supported the notion that Th1 and Th2 cells represent true lineages by demonstrating the epigenetic modification state of a number of signature-cytokine loci, including Ifng locus in Th1 cells (Hatton et al., 2006; Schoenborn et al., 2007) and Il4 locus in Th2 cells (Ansel et al., 2006).”
Tuning the Cytokine Responses: An Update on Interleukin (IL)-4 and IL-13 Receptor Complexes (2018, neutral): “The genomic locus, where IL-4 and IL-13 are produced (along with IL-5), is called the Th2 cytokine locus, which is located on chromosome 5 in humans and on chromosome 11 in mice and is under the control of the locus control region (LCR) of the Rad 50 gene (10, 11).”
Epigenetic control of T-helper-cell differentiation (2009, result): “In contrast to these protective functions of T H cells, inappropriate T H 2-cell responses give rise to allergic diseases, whereas autoimmune diseases result from inappropriate T H 1- and T H 17-cell response”
IL-2 Family Cytokines: New Insights into the Complex Roles of IL-2 as a Broad Regulator of T helper Cell Differentiation (2011, background): “produce IL-4, IL-5, and IL-13 and participate in controlling humoral immunity to extracellular parasites and allergic inflammatory responses [18,22]; and TGF-b/IL6 and IL-23/IL-21/STAT3 and RORgt together promote differentiation into Th17 cells, which produce IL-17A, IL-17F, and IL-22 and are involv”
Chromatin signatures in multipotent human hematopoietic stem cells indicate the fate of bivalent genes during differentiation (2009, background): “…et al., 2007), and changes in chromatin structure have been reported during differentiation of ESCs (Bernstein et al., 2005; Chambeyron and Bickmore, 2004; Mikkelsen et al., 2007; Mohn et al., 2008) and other cells such as T cells and red blood cells (Ansel et al., 2006; de Laat et al., 2008).”
Interleukin-2 and Inflammation Induce Distinct Transcriptional Programs that Promote the Differentiation of Effector Cytolytic T Cells (2010, background): “Prf1 Transcription Is Regulated by Recruitment of RNA Polymerase II TCR stimulation of naive CD4 T cells leads them to differentiate into distinct subsets with respect to expression of cytokine genes, a process that involves differential chromatin remodeling of specific cytokine gene loci ( Ansel et”