Brain-derived Neurotrophic Factor Is Stored in Human Platelets and Released by Agonist Stimulation

By H. Fujimura, C. Altar, Ruoyan Chen, Takashi Nakamura, T. Nakahashi, J. Kambayashi, Bing Sun, N. Tandon. Thrombosis and Haemostasis, 2002

789 citations recorded by the source corpus.

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

The role of BDNF and its receptors in depression and antidepressant drug action: Reactivation of developmental plasticity (2010, background): “BDNF is taken up into platelets through an uncharacterized transport mechanism (Fujimura et al., 2002), but may also be translated in platelets from mRNA derived from megakaryocytes.”
Brain-derived neurotrophic factor is produced by skeletal muscle cells in response to contraction and enhances fat oxidation via activation of AMP-activated protein kinase (2009, background): “Since platelets are known to store and release BDNF [35], we examined the relationship between circulating BDNF and platelet count.”
Brain-Derived Neurotrophic Factor in Brain Disorders: Focus on Neuroinflammation (2018, background): “Around 90% of the BDNF in blood is stored within platelets [18].”
Effects of Aerobic Exercise on Mild Cognitive Impairment (2010, neutral): “Although BDNF is highly concentrated in the central nervous system, it is also stored and released by activated blood platelets.(47) Thus, we assayed platelet factor 4 to estimate platelet activity and adjusted total BDNF levels by these values.”
Molecular mechanisms and potential therapeutical targets in Huntington's disease. (2010, background): “The BDNF in blood derives from synthesis in mononuclear blood cells and endothelial cells, and from platelets release as well as, although to a very minor extent, from the passage through the blood-brain barrier (195).”