Brain-derived neurotrophic factor is produced by skeletal muscle cells in response to contraction and enhances fat oxidation via activation of AMP-activated protein kinase

By V. Matthews, Maj-Briit Astrom, M. H. Chan, C. Bruce, K. Krabbe, O. Prelovsek, Thorbjorn C A Akerstrom, C. Yfanti, C. Broholm, O. Mortensen and 7 more. Diabetologia, 2009

647 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Molecular Biology, Physiology

View Paper: https://www.semanticscholar.org/paper/4a8929d0be521f621ff5750ab854a4eab70f134f

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cellular and Molecular Neuroscience

1. B. K. Pedersen
2. B. Saltin

In Molecular Biology

1. M. C. Severinsen
2. B. K. Pedersen
3. B. Saltin

In Physiology

1. M. C. Severinsen
2. B. Saltin
3. B. K. Pedersen
4. Haiming Cao

Citations in the corpus

• The diseasome of physical inactivity – and the role of myokines in muscle–fat cross talk (2009, background): “We studied whether skeletal muscle would produce BDNF in response to exercise (Matthews et al. 2009).”
• Exercise is the real polypill. (2013, background): “Several tissues, such as contracting muscles (111, 152, 293) or platelets (465), can express BDNF.”
• Muscle–Organ Crosstalk: The Emerging Roles of Myokines (2020, background): “In contrast, BDNF is identified as a myokine capable of enhancing AMPK activation and hence lipid oxidation in an autocrine or paracrine manner (63).”
• Muscles and their myokines (2011, background): “BDNF in response to exercise (Matthews et al., 2009) and found”
• Metabolic Syndrome and Insulin Resistance: Underlying Causes and Modification by Exercise Training (2013, neutral): “Muscle-derived factors including IL-6 (100, 101, 492, 493) IL-15 (514), BNDF (365, 424, 520), FGF21 (29, 64, 132, 164, 311, 349), and Follistatin-like 1 (482, 484), and SPARC (466) are a few putative myokines currently under investigation.”
• Exercise as medicine – evidence for prescribing exercise as therapy in 26 different chronic diseases (2015, background): “Every time physical activity occurs, the BDNF level increases in the brain, blood, and muscles (Pedersen, 2011) and it is possible that BDNF represents a mechanism by which physical activity can influence symptoms of depression (Matthews et al., 2009; Pedersen et al., 2009; Huang et al., 2014).”