A minicircuitry comprised of microRNA-223 and transcription factors NFI-A and C/EBPalpha regulates human granulopoiesis.

By F. Fazi, A. Rosa, Alessandro Fatica, V. Gelmetti, Maria Laura De Marchis, C. Nervi, I. Bozzoni. Cell, 2005

1,064 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/117bfae9362be1a6c1454ac0c6ed0c7689327802

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Citations in the corpus

Aberrant Expression of Oncogenic and Tumor-Suppressive MicroRNAs in Cervical Cancer Is Required for Cancer Cell Growth (2008, background): “fibroblast angiotensin II type 1 receptor expression [64]; miR-223, along with the transcription factors C/EBPa and NFI-A, participates in regulation of granulocytic differentiation by suppressing the transcription of NFI-A mRNA [65].”
Roles for microRNAs in conferring robustness to biological processes. (2012, positive): “And (3) there are often other networkmotifs involving a cell-type-specific miRNA that redundantly reinforce the same cell fate decision, as with the mutual negative feedback loop between miR-223 and NFI-A in granulocytes (Fazi et al., 2005).”
Physiological and pathological roles for microRNAs in the immune system (2010, background): “miR-424 promoted monocytic differentiation by inhibiting the expression of nuclear factor I/A ( NFIA ), which is important for myeloid cell differentiation and had also been shown previously to be targeted by miR-223 during granulocyte differentiation in vitro”
The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1 (2008, background): “In some cases, an individual microRNA can act as a developmental switch by regulating a key target mRN”
The sequential action of miR156 and miR172 regulates developmental timing in Arabidopsis. (2009, neutral): “There is growing evidence from animal systems that miRNAregulated transcription factors frequently regulate the transcription of their cognate miRNAs (Fazi et al., 2005; Johnson et al., 2005; Kim et al., 2007; Varghese and Cohen, 2007).”
MicroRNAs: new regulators of immune cell development and function (2008, background): “Granulocytic differentiation is restored by enforced expression of miR-223 in leukemic blast cells; this suggests a physiological function for miR-223 in this process, which is disrupted in diseas”
MicroRNA regulation by RNA-binding proteins and its implications for cancer (2011, background): “Intriguingly, this competition is induced by CEPBA-stimulated transcription, mainly of miR-328 and other miRNA gene”
Microvesicles Derived from Adult Human Bone Marrow and Tissue Specific Mesenchymal Stem Cells Shuttle Selected Pattern of miRNAs (2010, background): “Interestingly, also miR-223 was predicted to influence cell differentiation and development [59], in particular miR-223 appears to have a role in hematopoietic stem cell proliferation [60].”
MicroRNAs in development and disease. (2011, background): “Consistent with its developmental pattern, this gene is regulated by c/EBP (173, 190) and PU.”
Extensive post-transcriptional regulation of microRNAs and its implications for cancer. (2006, background): “Transcription of the pri-miRNA can be regulated, as has been demonstrated for tissue-specific miRNAs (Fazi et al. 2005; O’Donnell et al. 2005; Zhao et al. 2005; Chen et al. 2006).”