Patterns of linkage disequilibrium in the human genome

By Kristin G. Ardlie, Leonid Kruglyak, Mark Seielstad. Nature reviews genetics, 2002

1,052 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/111c45bce7342eae50026125ea44b67d6acc55cf

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Genetics

In Molecular Biology

Citations in the corpus

Candidate-gene approaches for studying complex genetic traits: practical considerations (2002, background): “Therefore, assumptions about the ability to detect associations on the basis of linkage disequilibrium and about the predictive power of haplotypes need to be carefully evaluate”
Status and Prospects of Association Mapping in Plants (2008, background): “h ough LD is af ected by many factors (Ardlie et al., 2002), LD due to linkage is the net result of all the recombination events that occurred in a population since the origin of an allele by mutation, providing a greater opportunity for recombination to take place between any two closely linked loc”
Evaluation of Genetic Diversity and Genome‐wide Linkage Disequilibrium among U.S. Wheat (Triticum aestivum L.) Germplasm Representing Different Market Classes (2007, result): “Nonetheless, the nonuniform chromosome distribution of LD observed in this study is comparable to the fi ndings in humans (Huttley et al., 1999; Ardlie et al., 2002), maize (Stich et al., 2005), and a previous study in wheat (Breseghello and Sorrells, 2006).”
The linkage disequilibrium and the selection of genetic markers for association studies in European populations (2007, background): “Recurrent mutation (in either mutant or marker locus) might also decrease the association between these loci, but it would be a very rare case and there is no evidence that it contributes significantly to the erosion of LD between SNPs (Ardlie et al. 2002).”
Accuracy of Predicting the Genetic Risk of Disease Using a Genome-Wide Approach (2008, neutral): “In humans, most LD stretches for 10 to 30 kb, while some linkage disequilibrium blocks may be .100 kb [ 25 ].”
An Exact Nonparametric Method for Inferring Mosaic Structure in Sequence Triplets (2007, background): “…2003; Moya et al. 2004; Wilson et al. 2005) and the characterization of linkage disequilibrium in large genomes (Pritchard and Przeworski 2001; Ardlie et al. 2002; Gabriel et al. 2002) to theoretical questions about clonality and the definitions of clonal and nearly clonal organisms (Maynard…”
Association mapping of yield and its components in rice cultivars (2007, background): “Many factors affect LD (Ardlie et al. 2002), but the most probable cause of the high level of LD in rice is that it is a selfpollinated species.”
From genotype to phenotype: unraveling the complexities of cold adaptation in forest trees (2003, background): “Furthermore, the extent of LD varies in different regions of the genome (reviewed in Tenaillon et al. 2001; Ardlie et al. 2002; Nordborg et al. 2002).”
Marker-Assisted Plant Breeding: Principles and Practices (2015, background): “estimates take into account differences in allele frequencies and show much less inflation than D0 estimates (Ardlie et al. 2002).”
The future of association studies: gene-based analysis and replication. (2004, background): “some nearby variants means that full information often can be obtained by genotyping only a subset of the variants and by considering their joint haplotypes (Daly et al. 2001; Johnson et al. 2001; Patil et al. 2001; Gabriel et al. 2002; Ardlie et al. 2002).”
Genetics and Genomics of Core Short Tandem Repeat Loci Used in Human Identity Testing (2006, background): “However, the occurrence of loci on the same chromosome that are many millions of base pairs apart should not impact reliable use of the product rule as even loci less than a million bases apart can be shuffled separately because of recombination hot spots and patterns of linkage disequilibrium (60).”
Linkage disequilibrium levels in Bos indicus and Bos taurus cattle using medium and high density SNP chip data and different minor allele frequency distributions (2014, background): “This correlation mainly arises from physical closeness but can also be influenced by various evolutionary processes and historical population events (Reich et al., 2001; Ardlie et al., 2002; Khatkar et al., 2008).”
ACTN3 genotype is associated with human elite athletic performance. (2003, background): “The distance over which “useful” linkage disequilibrium extends varies considerably between loci (Reich et al. 2001); however, a distance of 10 kb has been proposed as a rough average value on the basis of population modeling (Ardlie et al. 2002).”
Calibrating a coalescent simulation of human genome sequence variation. (2005, background): “Perhaps the most obvious discrepancy occurs in predictions of linkage disequilibrium, the nonrandom association of nearby alleles (Frisse et al. 2001; Pritchard and Przeworski 2001; Ardlie et al. 2002).”
An intronic SNP in a RUNX1 binding site of SLC22A4, encoding an organic cation transporter, is associated with rheumatoid arthritis (2003, methodology): “and approaches based on target genes, LD mapping with SNPs for candidate regions coupled with whole-genome screening is considered to be a useful method for genetic association studie”