The future of association studies: gene-based analysis and replication.

By Benjamin M. Neale, Pak Chung Sham. American Journal of Human Genetics, 2004

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Five years of GWAS discovery. (2012, background): “It has become clear that human genetic variants, such as single nucleotide polymorphisms (SNPs), can in cis affect the expression of nearby genes [1], [2].”
Gene-Wide Analysis Detects Two New Susceptibility Genes for Alzheimer's Disease (2014, background): “It is therefore likely that the power to detect association might be enhanced by exploiting information from multiple signals within genes encompassed by gene-wide statistical approaches[12].”
A versatile gene-based test for genome-wide association studies. (2010, background): “Gene-based tests for association are increasingly being seen as a useful complement to genome-wide association studies (GWAS).(1) A gene-based approach considers association between a trait and all markers (usually SNPs) within a gene rather than each marker individually.”
GATES: a rapid and powerful gene-based association test using extended Simes procedure. (2011, background): “In these tests, all the SNPs or haplotypes in the gene are entered as predictor variables simultaneously, except for redundant SNPs,whose inclusionwould result in collinearity.(6)However, a simple regression analysis might suffer from low statistical power if many SNPs or haplotypes are included, re”