An intronic SNP in a RUNX1 binding site of SLC22A4, encoding an organic cation transporter, is associated with rheumatoid arthritis

By S. Tokuhiro, R. Yamada, X. Chang, A. Suzuki, Y. Kochi, T. Sawada, Masakatsu Suzuki, Miyuki Nagasaki, M. Ohtsuki, Mitsuru Ono and 10 more. Nature Genetics, 2003

632 citations recorded by the source corpus.

Subfields: Oncology, Rheumatology

View Paper: https://www.semanticscholar.org/paper/44f54bebeef812ac115a62ec05eacd52a72aea7c

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Oncology

1. M. Roth
2. A. Obaidat
3. J. Matsuda
4. B. Hagenbuch
5. Laurie H. Glimcher
6. L. Gapin
7. J. L. Boyer
8. M. Kronenberg

In Rheumatology

1. David Altshuler

Citations in the corpus

• Replication of putative candidate-gene associations with rheumatoid arthritis in >4,000 samples from North America and Sweden: association of susceptibility with PTPN22, CTLA4, and PADI4. (2005, background): “Specific alleles at PADI4 (Suzuki et al. 2003), CTLA4 (Rodriguez et al. 2002; Vaidya et al. 2002), IL4 (Cantagrel et al. 1999; Maksymowych et al. 2002), SLC22A4 (Tokuhiro et al. 2003), MIF (Barton et al. 2003), and TNFRSF1B (Barton et al. 2001; Dieude et al. 2002; Kyogoku et al. 2003) have been asso”
• T-bet regulates the terminal maturation and homeostasis of NK and Valpha14i NKT cells. (2004, background): “…anti-CD44 clone IM7, FITC-binding sites have been recently associated with suslabeled anti-CD19 clone MB19-1, PE-labeled anti-CD122 clone 5H4ceptibility to autoimmune diseases (Helms et al., 2003; (eBioscience, San Diego, CA) FITC-labeled anti-Ly-49C/I clone 5E6, Tokuhiro et al., 2003).”
• Polyspecific Organic Cation Transporters: Structure, Function, Physiological Roles, and Biopharmaceutical Implications (2007, background): “In human the strongest expression was observed in kidney, skeletal muscle, bone marrow, and trachea (31,75).”
• Functional variants of OCTN cation transporter genes are associated with Crohn disease (2004, result): “Our data and a previous study of rheumatoid arthriti”
• OATPs, OATs and OCTs: the organic anion and cation transporters of the SLCO and SLC22A gene superfamilies (2012, background): “OCTN1 transcription was altered by both the RUNX1 transcription factor and TNF-a in vitro (Tokuhiro et al., 2003).”
• A missense single-nucleotide polymorphism in a gene encoding a protein tyrosine phosphatase (PTPN22) is associated with rheumatoid arthritis. (2004, neutral): “Although interesting associations have been reported (Suzuki et al. 2003; Tokuhiro et al. 2003), only alleles at the HLA-DRB1 locus have consistently demonstrated both linkage and association (Seldin et al 1999).”