Candidate-gene approaches for studying complex genetic traits: practical considerations

By H. Tabor, N. Risch, Richard M. Myers. Nature reviews genetics, 2002

1,155 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/823c9ad47ad80ff35b74d0c3feb31f50442a5f2c

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Genetics

In Molecular Biology

Citations in the corpus

Landscape genetics: combining landscape ecology and population genetics (2003, background): “Finally, they can often be identified in candidate genes with potentially important functions [ 51 ].”
FASTSNP: an always up-to-date and extendable service for SNP function analysis and prioritization (2006, methodology): “Based on previous studies of the functional effects of polymorphisms, Tabor et al. ( 1 ) presented a prioritization strategy that associates the relative risk of a SNP with its location and the type of sequence variants.”
Status and Prospects of Association Mapping in Plants (2008, background): “Because a key objective of this approach is to identify SNPs that are causal of phenotypic variation, those with a higher likelihood to alter protein function (coding SNPs) or gene expression (regulatory SNPs) should be a top priority for genotyping (Tabor et al., 2002).”
Strategy for investigating interactions between measured genes and measured environments. (2005, background): “Candidate genes have empirical evidence of functional physiological significance in brain systems relevant to the disorder.(88) However, this is not enough to frame hypotheses in GxE research.”
An intronic SNP in a RUNX1 binding site of SLC22A4, encoding an organic cation transporter, is associated with rheumatoid arthritis (2003, methodology): “and approaches based on target genes, LD mapping with SNPs for candidate regions coupled with whole-genome screening is considered to be a useful method for genetic association studie”
Genomic selection in forest tree breeding: the concept and an outlook to the future (2014, background): “possible roles (a priori hypotheses) in the phenotype, and the associations between DNA variants and phenotypes are tested (Tabor et al. 2002).”
Meta-analysis of genetic association studies supports a contribution of common variants to susceptibility to common disease (2003, background): “In principle, the inconsistency may be due to false positive studies, false negative studies or true variability in association among different population”