Core-shell nanoscale coordination polymers combine chemotherapy and photodynamic therapy to potentiate checkpoint blockade cancer immunotherapy
By Chunbai He, Xiaopin Duan, Nining Guo, Christina Chan, Christopher Poon, R. Weichselbaum, Wenbin Lin. Nature Communications, 2016
643 citations recorded by the source corpus.
Advanced colorectal cancer is one of the deadliest cancers, with a 5-year survival rate of only 12% for patients with the metastatic disease. Checkpoint inhibitors, such as the antibodies inhibiting the PD-1/PD-L1 axis, are among the most promising immunotherapies for patients with advanced colon cancer, but their durable response rate remains low. We herein report the use of immunogenic nanoparticles to augment the antitumour efficacy of PD-L1 antibody-mediated cancer immunotherapy. Nanoscale coordination polymer (NCP) core-shell nanoparticles carry oxaliplatin in the core and the photosensitizer pyropheophorbide-lipid conjugate (pyrolipid) in the shell (NCP@pyrolipid) for effective chemotherapy and photodynamic therapy (PDT). Synergy between oxaliplatin and pyrolipid-induced PDT kills tumour cells and provokes an immune response, resulting in calreticulin exposure on the cell surface, antitumour vaccination and an abscopal effect. When combined with anti-PD-L1 therapy, NCP@pyrolipid mediates regression of both light-irradiated primary tumours and non-irradiated distant tumours by inducing a strong tumour-specific immune response. Blockade of PD-L1 is usually not very effective in colon cancer patients. Here, the authors show the efficacy of PD-L1 blockade in combination with coordination polymer nanoparticles carrying oxaliplatin and a photosensitizer to induce anti-tumor immunity in metastatic models of colon cancer.
Subfields: Biomedical Engineering, Oncology, Pulmonary and Respiratory Medicine
View Paper: https://www.semanticscholar.org/paper/1a002b90990917f19c6e28613f4a5f760fce408a
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In Biomedical Engineering
Citations in the corpus
- Tumor Targeting via EPR: Strategies to Enhance Patient Responses (2018, background): “This combination of chemotherapy, antitumor immunity and PDT that synergized with immune checkpoint blockade showed the highest response rate compared to all controls in a bilateral colon carcinoma tumor model, with even an induction of abscopal effects and with induced cell death in distant tumors ”