JAKs and STATs in Immunity, Immunodeficiency, and Cancer
By J. O’Shea, S. Holland, Louis Staudt. New England Journal of Medicine, 2013
827 citations recorded by the source corpus.
A large number of cytokines signal through the JAK–STAT pathway. Abnormal function of this pathway may lead to a variety of diseases. Targeting the defects in this signaling pathway has already led to treatment advances, and further advances are likely.
View Paper: https://www.semanticscholar.org/paper/10de6daf2931d60fe1714edabb25af21466dbc32
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Citations in the corpus
- The IUPHAR/BPS Guide to PHARMACOLOGY in 2018: updates and expansion to encompass the new guide to IMMUNOPHARMACOLOGY (2017, background): “Most chronic diseases, including ageing, have an immune-inflammatory component (10); auto-immunity is a serious problem (11,12), and the progress of infections depends on immune and inflammatory responses (13).”
- JAK–STAT Signaling as a Target for Inflammatory and Autoimmune Diseases: Current and Future Prospects (2017, background): “The active STATs can then translocate into the nucleus where they act as transcription factors to regulate gene expression [1, 26, 27].”
- The JAK/STAT signaling pathway: from bench to clinic (2021, background): “In addition, TNF is able to activate this pathway by causing STAT3 phosphorylation.(300,301) Besides, STAT4 and STAT6 polymorphisms play central roles in RA.”
- The role of JAK-STAT signaling pathway and its regulators in the fate of T helper cells (2017, background): “Therefore, they translocate to the nucleus and bind to specific DNA sequences either to activate or suppress gene transcription [13, 15].”
- The JAK-STAT Pathway: Impact on Human Disease and Therapeutic Intervention (2015, background): “In its classic presentation, the diagnosis of SCID is not difficult.”