Metabolic requirements for the maintenance of self-renewing stem cells

By Keisuke Ito, T. Suda. Nature reviews. Molecular cell biology, 2014

966 citations recorded by the source corpus.

A distinctive feature of stem cells is their capacity to self-renew to maintain pluripotency. Studies of genetically-engineered mouse models and recent advances in metabolomic analysis, particularly in haematopoietic stem cells, have deepened our understanding of the contribution made by metabolic cues to the regulation of stem cell self-renewal. Many types of stem cells heavily rely on anaerobic glycolysis, and stem cell function is also regulated by bioenergetic signalling, the AKT–mTOR pathway, Gln metabolism and fatty acid metabolism. As maintenance of a stem cell pool requires a finely-tuned balance between self-renewal and differentiation, investigations into the molecular mechanisms and metabolic pathways underlying these decisions hold great therapeutic promise.

Subfields: Cell Biology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/5ceb63a4646ba9b7fbb4e2223ba6505bbdf56ca9

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Citations in the corpus

Human haematopoietic stem cell lineage commitment is a continuous process (2017, positive): “…4) and associated with typical stem cell properties such as cell cycle quiescence, low expression of the entire gene expression machinery, low total RNA content (measured by mRNA reads per in vitro spike in RNA read), low cellular respiration 29 , low CD38 and high CD90 surface expression 5 (Fig.”
Fundamentals of cancer metabolism (2016, background): “Normal proliferating cells, such as immune cells and stem cells, also reprogram theirmetabolism in amanner similar to cancer cells (140, 141).”