Vancomycin-resistant Enterococcus domination of intestinal microbiota is enabled by antibiotic treatment in mice and precedes bloodstream invasion in humans.

By C. Ubeda, Y. Taur, Robert R. Jenq, Michele J. Equinda, Tammy Son, M. Samstein, A. Viale, Nicholas D. Socci, M. V. D. van den Brink, M. Kamboj and 1 more. Journal of Clinical Investigation, 2010

859 citations recorded by the source corpus.

Subfields: Food Science, Infectious Diseases, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/17914a9a90f31e25ca17f2f1e75d09ca24e50740

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Citations in the corpus

The effects of intestinal tract bacterial diversity on mortality following allogeneic hematopoietic stem cell transplantation. (2014, result): “Prior studies have shown that the intestinal microbiota of patients undergoing allo-HSCT often loses diversity, resulting in domination by a range of microbes that can enter the bloodstream and cause septicemia, particularly in times of neutropenia and mucosal barrier injury.(3,16) In this study, we”
The microbial metabolites, short chain fatty acids, regulate colonic Treg cell homeostasis (2013, background): “The antibiotic vancomycin, which targets Gram-positive bacteria and disrupts the gut microbiota (12), reduces cTregs to similar levels as observed in GF mice (7) (fig.”
Antibiotic-Induced Changes in the Intestinal Microbiota and Disease. (2016, background): “VRE colonizes the intestine following antibiotic treatment, before spreading to the bloodstream, and thus, represents a major threat for hospitalized patients [83].”
Conducting a Microbiome Study (2014, background): “Some of these factors, notably antibiotic use, have effects strong enough that they are often exclusion criteria (Cho et al., 2012; Dethlefsen et al., 2008; Dethlefsen and Relman, 2011; Ubeda et al., 2010).”
Antimicrobial Resistance in ESKAPE Pathogens (2020, background): “The entry of VREfm into the bloodstream of hospitalized patients is typically preceded by antibiotic exposure, enabling VREfm to become the predominant species in the gastrointestinal tract (45, 46).”
Expansion of intestinal Prevotella copri correlates with enhanced susceptibility to arthritis (2013, methodology): “DNA was extracted using a combination of the MoBio Power Soil kit (Mo Bio Laboratories, Inc, Carlsbad, CA, USA) and a mechanical disruption (bead-beater) method based on a previously described protocol (Ubeda et al., 2010).”
The intestinal microbiota modulates the anticancer immune effects of cyclophosphamide (2013, background): “Anticancer chemotherapeutics often cause mucositis (a debilitating mucosal barrier injury associated with bacterial translocation) and neutropenia, two complications that require treatment with antibiotics, which in turn can result in dysbiosis (4, 5).”
Antibiotics and the Human Gut Microbiome: Dysbioses and Accumulation of Resistances (2016, background): “…clinical setting, intestinal domination by vancomycin-resistant Enterococcus has been shown to precede bloodstream infection by this pathogen, and experimental work in mice has established that antibiotic treatment sets the stage for the intestinal outgrowth of this bacterium (Ubeda et al., 2010).”
Bacterial Biofilms: Development, Dispersal, and Therapeutic Strategies in the Dawn of the Postantibiotic Era (2013, background): “Although over the years antibiotics have proven critical in eliminating bacterial pathogens, overwhelming evidence indicates that they extensively damage the host microbiota, creating an environment where opportunistic pathogens can prevail, and they increase the selective pressure toward antibiotic”
Impact of antibiotics on the human microbiome and consequences for host health (2022, background): “For example, a study reported a decrease in abundance of Gram‐negative bacteria in the gut by vancomycin which is a Gram positive‐targeting antibiotic (Ubeda et al., 2010).”
The gut microbiota plays a protective role in the host defence against pneumococcal pneumonia (2015, background): “36 37 Details on the phagocytosis and cell stimulation experiments are provided in the online supplementary ﬁ le.”
Tryptophan catabolites from microbiota engage aryl hydrocarbon receptor and balance mucosal reactivity via interleukin-22. (2013, neutral): “Accordingly, treatment with vancomycin, which inhibits Th17-inducing SFB in the ileum (Ivanov et al., 2009), as well as Bacteroidetes from the cecum (Ubeda et al., 2010), slightly decreased antifungal resistance in WT, but not in Ido1 / , mice (Figure S6D), a finding pointing to a minor role for…”
Intestinal domination and the risk of bacteremia in patients undergoing allogeneic hematopoietic stem cell transplantation. (2012, background): “In this and our previous studies [15], bloodstream infections during allo-HSCT are frequently preceded by intestinal domi-”