Dysbiosis of the Gut Microbiota Is Associated with HIV Disease Progression and Tryptophan Catabolism

By Ivan Vujkovic-Cvijin, R. Dunham, S. Iwai, M. C. Maher, Rebecca G. Albright, M. J. Broadhurst, Ryan D. Hernandez, M. Lederman, Yong Huang, M. Somsouk and 4 more. Science Translational Medicine, 2013

695 citations recorded by the source corpus.

Subfields: Biological Psychiatry, Emergency Medicine, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/c8190720e1b6f09887dcca0d163da546592c3ee2

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In Molecular Biology

1. Lan Lin
2. Steven G. Deeks
3. Jianqiong Zhang
4. J. McCune

Citations in the corpus

• Role of intestinal microbiota and metabolites on gut homeostasis and human diseases (2017, background): “Moreover, HIV-infected subjects have elevated epithelial permeability, systemic microbial translocation, and increased serum inflammatory status, which are considered to propel the disease progression to AIDS [195, 196].”
• HIV-Infected Individuals with Low CD4/CD8 Ratio despite Effective Antiretroviral Therapy Exhibit Altered T Cell Subsets, Heightened CD8+ T Cell Activation, and Increased Risk of Non-AIDS Morbidity and Mortality (2014, background): “Such induction may occur even after the initiation of effective ART, as shown by increased K/T ratios in some if not all [52].”
• Gut Microbiota Regulation of Tryptophan Metabolism in Health and Disease. (2018, neutral): “metabolites such as 3-hydroxyanthranilic acid (Vujkovic-Cvijin et al., 2013) which has neurotoxic effects (O'Farrell et al.”