Stem cell division is regulated by the microRNA pathway

By Steven D. Hatfield, H. Shcherbata, Karin A. Fischer, K. Nakahara, Richard W. Carthew, H. Ruohola-Baker. Nature, 2005

727 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology, Plant Science

View Paper: https://www.semanticscholar.org/paper/1003d652ff0445fd76fbf82a7ec2c98022c580eb

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

In Molecular Biology

In Plant Science

Citations in the corpus

DGCR8 is essential for microRNA biogenesis and silencing of embryonic stem cell self-renewal (2007, background): “The accumulation of DGCR8-deficient ES cells in G1 is reminiscent of the result of loss of the miRNA-specific Dicer gene, Dcr-1 , in the Drosophila melanogaster germ lin”
A small piece in the cancer puzzle: microRNAs as tumor suppressors and oncogenes (2006, background): “…came from studies in model systems where it was demonstrated that specific miRNAs contribute to the regulation of cellular differentiation, proliferation and apoptosis (Lee et al., 1993; Wightman et al., 1993; Reinhart et al., 2000; Brennecke et al., 2003; Xu et al., 2003; Hatfield et al., 2005).”
MicroRNAs in cell proliferation, cell death, and tumorigenesis (2006, background): “Drosophila with a null mutation of dicer-1 (dcr-1), which is required for miRNA processing, exhibited abnormalities in germline stem cell (GSC) function (Hatfield et al, 2005).”
MicroRNAs: key regulators of stem cells (2009, background): “Dicer1-null germline stem cells display delayed G1–S-phase transitio”
Non-coding RNA. (2006, background): “The expression of many miRNAs is regulated and miRNAs have been shown to be central to a wide range of developmental processes, including developmental timing, cell proliferation, left–right patterning, neuronal cell fate, apoptosis and fat metabolism [for reviews see (8,133–135,143)], as well as ne”
A genetic screen implicates miRNA-372 and miRNA-373 as oncogenes in testicular germ cell tumors. (2006, background): “Intriguingly, Drosophila germ cells and mouse embryonic stem (ES) cells require miRNAs to proliferate (Forstemann et al., 2005; Hatfield et al., 2005).”
MicroRNA functions in animal development and human disease (2005, background): “Finally, the deletion of Dicer-1 in Drosophila results in a growth defect in germline stem cells (Hatfield et al., 2005) (see below).”
The Role of MicroRNAs in Human Diseases (2010, background): “Other regulatory roles include neuronal gene expression (45) , brain morphogenesis (46) , muscle differentiation (47) , and stem cell division (48) .”
Mechanisms of miRNA-Mediated Gene Regulation from Common Downregulation to mRNA-Specific Upregulation (2014, background): “It was primarily acknowledged that miRNAs result in gene expression repression at both the level of mRNA stability by conducting mRNA degradation and the level of translation (at initiation and after initiation) by inhibiting protein translation or degrading the polypeptides through binding…”
microRNAs as oncogenes and tumor suppressors. (2007, background): “…genes control multiple biological processes, including developmental timing (Reinhart et al., 2000), stem cell division (Cheng et al., 2005b; Hatfield et al., 2005; Houbaviy et al., 2003; Suh et al., 2004; Zhang et al., 2006f), apoptosis (Cheng et al., 2005a; Cimmino et al., 2005; Tanno et…”