UNC93B1 delivers nucleotide-sensing toll-like receptors to endolysosomes

By You-Me Kim, Melanie M. Brinkmann, M. Paquet, Hidde L. Ploegh. Nature, 2008

731 citations recorded by the source corpus.

Subfields: Endocrinology, Immunology

View Paper: https://www.semanticscholar.org/paper/0f3e908da05219a4fee3b549be996e1e0a8af1a3

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Endocrinology

1. O. Takeuchi
2. G. Barton
3. Jonathan C. Kagan
4. Taro Kawai
5. Shizuo Akira

In Immunology

1. Shizuo Akira
2. Taro Kawai
3. O. Takeuchi
4. Jonathan C. Kagan
5. G. Barton
6. R. Medzhitov
7. I. Zanoni
8. D. Davies

Citations in the corpus

• A cell biological view of Toll-like receptor function: regulation through compartmentalization (2009, methodology): “These data have been used to support a model in which TLR9 traffics from the ER to the endolysosome via an unconventional route, bypassing the Golgi completel”
• CD14 controls the LPS-induced endocytosis of Toll-like Receptor 4 (2011, background): “868 Cell 147, 868–880, November 11, 2011 ª2011 Elsevier Inc. Virtually all of our knowledge of TLR transport is limited to regulators that promote the folding or transport of newly synthesized receptors (e.g., GP96, PRAT4a, and UNC93B1) (Kim et al., 2008; Takahashi et al., 2007; Yang et al., 2007).”
• Innate Immunity to Virus Infection (2009, background): “TLR7 and TLR9 from the ER to endosomes (83, 84).”
• The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors (2010, background): “TLR9 and TLR7 are exclusively sequestered in the ER in unstimulated cells and rapidly traffic to endolysosomes after ligand stimulatio”
• The Structural Biology of Toll-Like Receptors (2011, background): “TLRs that recognize nucleic acid PAMPs interact through their transmembrane domains with a multispan transmembrane protein known as UNC93B, which directs these TLRs to endocytic compartments (Brinkmann et al., 2007;Kim et al., 2008).”
• Pattern recognition receptors and inflammation. (2010, background): “…into the nucleus to induce expression of type I IFN genes. revealed that UNC93B1 (an ER protein with 12 membrane-spanning domains) is responsible for TLR3, TLR7, and TLR9 signaling by governing the translocation of these TLRs from the ER to the endolysosome (Kim et al., 2008; Tabeta et al., 2006).”
• Innate Immune Pattern Recognition: A Cell Biological Perspective (2015, neutral): “The transport of TLRs to endosomes is also tightly controlled and requires interaction with a multipass transmembrane chaperone called Unc93B1 to exit the endoplasmic reticulum (176, 177).”