Differential control of learning and anxiety along the dorso-ventral axis of the dentate gyrus
By M. Kheirbek, L. Drew, N. Burghardt, Daniela Costantini, Lindsay E Tannenholz, S. Ahmari, Hongkui Zeng, André A. Fenton, R. Hen. Neuron, 2013
689 citations recorded by the source corpus.
The dentate gyrus (DG), in addition to its role in learning and memory, is increasingly implicated in the pathophysiology of anxiety disorders. Here, we show that, dependent on their position along the dorso-ventral axis of the hippocampus, DG granule cells (GCs) control specific features of anxiety and contextual learning. Using optogenetic techniques to either elevate or decrease GC activity, we demonstrate that GCs in the dorsal DG control exploratory drive and encoding, not retrieval, of contextual fear memories. In contrast, elevating the activity of GCs in the ventral DG has no effect on contextual learning but powerfully suppresses innate anxiety. These results suggest that strategies aimed at modulating the excitability of the ventral DG may be beneficial for the treatment of anxiety disorders.
Subfields: Cellular and Molecular Neuroscience, Cognitive Neuroscience, Social Psychology
View Paper: https://www.semanticscholar.org/paper/3c538be529a4c5c54e7172e30f4e8504564c6a8d
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Citations in the corpus
- Memory Engram Cells Have Come of Age. (2015, neutral): “Spatially, non-selective inhibition of all dorsal DG neurons had no effect on memory recall, making them seem unnecessary for this process (Kheirbek et al., 2013).”
- Increasing Adult Hippocampal Neurogenesis is Sufficient to Reduce Anxiety and Depression-Like Behaviors (2015, background): “Numerous studies have now shown that the dorsal and ventral hippocampus have different gene expression, connectivity, and function (Fanselow and Dong, 2010; Kheirbek et al, 2013).”
- Distinct Contribution of Adult-Born Hippocampal Granule Cells to Context Encoding (2016, neutral): “These studies complement recent optogenetic studies describing a role for DGGCs inmemory processes (Denny et al., 2014; Gu et al., 2012; Kheirbek et al., 2013).”
- The role of adult hippocampal neurogenesis in brain health and disease (2018, background): “vation of ventral DG neurons by optogenetic approaches can reduce anxiety levels [150, 151], possibly by regulating The role of adult hippocampal neurogenesis in brain health and disease”
- Hippocampal Memory Traces Are Differentially Modulated by Experience, Time, and Adult Neurogenesis (2014, background): “001) are higher in the DG than in CA3, which may reflect a preferential role of the DG in encoding (Kheirbek et al., 2013; Lee and Kesner, 2004).”
- Entorhinal Cortical Ocean Cells Encode Specific Contexts and Drive Context-Specific Fear Memory. (2015, positive): “Inputs to CA3 from DG include both developmentally derived old DG-GCs and adult-generated young DG-GCs, which have been shown to play a role in contextual fear memory (Kheirbek et al., 2013).”
- Functional Dissociation of Adult-Born Neurons Along the Dorsoventral Axis of the Dentate Gyrus (2014, background): “…the longi- tudinal axis of the hippocampus reveal that the dorsal pole appears to regulate cognitive-related behaviors while the ventral pole mediates mood-related responses (Moser et al., 1995; Ferbinteanu and McDonald, 2001; Bannerman et al., 2002; Kjelstrup et al., 2002; Maren and Holt, 2004).”
- Transgenic mice for intersectional targeting of neural sensors and effectors with high specificity and performance (2015, neutral): “Although proved useful in many applications (Ackman et al., 2012; Haddad et al., 2013; Issa et al., 2014; Jackman et al., 2014; Kheirbek et al., 2013; Lee et al., 2014; Nguyen-Vu et al., 2013; Pi et al., 2013), we and others have also identified limitations in the sensitivity or functionality of the”