Links between innate and adaptive immunity via type I interferon.

By A. Le Bon, D. Tough. Current Opinion in Immunology, 2002

672 citations recorded by the source corpus.

Subfields: Immunology

View Paper: https://www.semanticscholar.org/paper/0e03d3c003550879113ad378e638ff6f821a5b74

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In Immunology

1. Shizuo Akira
2. Taro Kawai
3. R. Medzhitov
4. B. Beutler
5. R. Randall
6. S. Goodbourn
7. Robert Schreiber
8. H. Hemmi

Citations in the corpus

• Cell Biology of Ischemia/Reperfusion Injury (2012, background): “However, evidence for reciprocal regulatory activity between innate and adaptive immunity (Karp, 2010), combined with unequivocal demonstrations of the importance of T and B lymphocytes (Burne-Taney et al., 2003; Burne-Taney et al., 2005; Huang et al., 2007; Linfert et al., 2009; Yilmaz and…”
• The cytokine storm in COVID-19: An overview of the involvement of the chemokine/chemokine-receptor system (2020, neutral): “surface glycoproteins, cytokines and chemokines [57,58].”
• Innate immune recognition of viral infection (2006, background): “In particular, type I interferons (both IFN-β and the multiple IFN-α molecules) are the key cytokines produced after viral infection that mediate induction of both the innate immune response and the subsequent development of adaptive immunity to viruse”
• Dendritic cells: translating innate to adaptive immunity. (2006, background): “In addition, innate lymphocytes and interferons act back on the DCs to drive maturation, and on T and B lymphocytes to enhance adaptive immunity (reviewed in [8, 9]).”
• A critical function for type I interferons in cancer immunoediting (2005, background): “Type I interferon is considered to be an important link between innate and adaptive immunit”
• Lentivirus-delivered stable gene silencing by RNAi in primary cells. (2003, background): “Recognition of dsRNA by DC result in their maturation and the DC-GFP may have demonstrated some degree of maturation following lentivirus infection ( Le Bon and Tough 2002 ).”
• Ischemia/Reperfusion (2016, neutral): “the emerging concept that the innate and adaptive immune systems share reciprocal regulatory activities (410).”
• Interferons and viruses: an interplay between induction, signalling, antiviral responses and virus countermeasures. (2008, background): “Although IFN-c plays a major role in promoting the transition from innate to adaptive immune responses, IFN-a/b is also important in this regard and has profound immunomodulatory activity (reviewed by Le Bon & Tough, 2002).”
• Inferences, questions and possibilities in Toll-like receptor signalling (2004, background): “Interferon-β has a particularly important part to pla”
• Viral infection switches non-plasmacytoid dendritic cells into high interferon producers (2003, background): “jpg" NDATA ITEM> ]> Type I interferons (IFN-I) are important cytokines linking innate and adaptive immunit”
• The interferon response circuit: Induction and suppression by pathogenic viruses (2005, background): “2), because type I IFNs play a major role in shaping adaptive immune responses, in addition to their function in innate immunity (Le Bon and Tough, 2002).”