Viral infection switches non-plasmacytoid dendritic cells into high interferon producers

By S. Diebold, M. Montoya, H. Unger, L. Alexopoulou, P. Roy, L. Haswell, A. Al-Shamkhani, R. Flavell, P. Borrow, C. Reis e Sousa. Nature, 2003

645 citations recorded by the source corpus.

Subfields: Immunology, Infectious Diseases

View Paper: https://www.semanticscholar.org/paper/989b0706e403aa3f9110c65454af8cf2e6899df0

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Citations in the corpus

Toll-like receptors in innate immunity. (2004, neutral): “In TRIF-and TRAM-deﬁcient mice, inﬂammatory cytokine production induced by TLR2, TLR7 and TLR9 ligands was observed, as well as TLR4 ligand-induced phosphorylation of IRAK-1 (52,89).”
The RNA Helicase Lgp2 Inhibits TLR-Independent Sensing of Viral Replication by Retinoic Acid-Inducible Gene-I1 (2005, background): “A similar mechanism has been suggested for the influenza virus NS1 protein that has the propensity to sequester dsRNA, thereby inhibiting the TLR-independent induction of IFN- by influenza infection (46, 47).”
The interferon response circuit: Induction and suppression by pathogenic viruses (2005, background): “This cell type predominantly secretes high levels of IFN-a and represents the so-called natural interferon producing cells of the body (Colonna et al., 2002; Diebold et al., 2003).”
Cross-presentation of viral and self antigens by skin-derived CD103+ dendritic cells (2009, background): “(a) Confocal microscopy (left) and direct photography (right; box outlines primary (11) site) of HSV-1 in flank skin of C57BL/6 mice on day 2 after infection with HSV-1 by flank scarification.”
IRF-7 is the master regulator of type-I interferon-dependent immune responses (2005, background): “The robust production of IFN-a observed upon stimulation with the synthetic RNA polyuridylic acid (poly(U)), which activates the TLR9 subfamily TLR7(8)(14,15), was also abolished in Irf7 and Myd88 pDCs, but was normal in Irf3 pDCs (Fig.”
Cross‐presentation, dendritic cell subsets, and the generation of immunity to cellular antigens (2004, background): “There is little evidence that plasmacytoid DCs are important for antigen presentation in the induction phase of immunity, and their key property seems to be production of interferon ab (IFNab) (92, 93).”