Inferences, questions and possibilities in Toll-like receptor signalling

By B. Beutler. Nature, 2004

1,557 citations recorded by the source corpus.

Subfields: Cancer Research, Immunology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/a999915ea0e813c1c23f67eb12fbbc1e53f556bc

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

In Immunology

In Molecular Biology

Citations in the corpus

The Unc93b1 mutation 3d disrupts exogenous antigen presentation and signaling via Toll-like receptors 3, 7 and 9 (2006, background): “As the key receptors required for host awareness of microbial infection, TLRs mediate most phenomena associated with microbial infection”
At the crossroads of inflammation and cancer. (2004, background): “Rakoff-Nahoum man, is the NF- B pathway (Beutler, 2004).”
Inflammation and atherosclerosis: signaling pathways and therapeutic intervention (2022, background): “In mammals, a total of 13 TLRs have been identified to date, among which TLR1-10 functions in humans and TLR12-13 in mice,(120) and each TLR has the specificity for different ligands to a certain degree.(121) For example, heterodimerized TLR2/TLR1 binds to triacylated lipopeptides derived from mycop”
The S100A8–serum amyloid A3–TLR4 paracrine cascade establishes a pre-metastatic phase (2008, background): “The leucine-rich repeat domains of TLRs are involved in the recognition of various pathogen”
Human Gut Microbiota and Gastrointestinal Cancer (2018, background): “TLRs are confirmed to recognize diverse molecules from microbes and promote tumorigenesis [118].”
The interface between innate and adaptive immunity (2004, background): “Abnormal immune responses and disease Many of the diseases that afflict mankind are now thought to be the result of dysfunctional innate and/or adaptive immune response”
TLR Signaling Tailors Innate Immune Responses in Human Microglia and Astrocytes1 (2005, background): “Both IFN- and CXCL-10 are produced downstream of the MyD88-independent TLR signal transduction pathway, as shown in peripheral cells following the ligation of TLR3 and TLR4 (12, 13).”
Negative regulation of Toll-like receptor-mediated immune responses (2005, background): “All members of this superfamily signal in a similar manner owing to the presence of a conserved TIR DOMAIN in the cytosolic region, which activates common signalling pathways, most notably those leading to the activation of the transcription factor nuclear factor-κB (NF-κB) and stress-activated pr”