Molecular and neuronal substrate for the selective attenuation of anxiety.

By K. Löw, F. Crestani, R. Keist, D. Benke, I. Brünig, J. Benson, J. Fritschy, T. Rülicke, H. Bluethmann, H. Möhler and 1 more. Science, 2000

964 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Cognitive Neuroscience

View Paper: https://www.semanticscholar.org/paper/0dd43d80153f4bedce31c1f9cb1647711f0a2899

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cellular and Molecular Neuroscience

1. Richard W. Olsen
2. W. Sieghart
3. D. Volk
4. T. Steimer
5. D. Lewis
6. T. Hashimoto
7. U. Rudolph
8. D. Schoepp

In Cognitive Neuroscience

1. T. Steimer
2. Richard W. Olsen
3. U. Rudolph
4. W. Sieghart

Citations in the corpus

• International Union of Pharmacology. LXX. Subtypes of γ-Aminobutyric AcidA Receptors: Classification on the Basis of Subunit Composition, Pharmacology, and Function. Update (2008, background): “2 subunits (Low et al., 2000), and, under conditions of high receptor occupancy, also by (cid:2) 3 GABA A -Rs (Dias et al., 2005; Yee et al., 2005; discussed by Mo¨hler, 2007).”
• Variations in GABRA2, encoding the alpha 2 subunit of the GABA(A) receptor, are associated with alcohol dependence and with brain oscillations. (2004, background): “Our finding of very strong LD with alcohol dependence and with brain oscillations across the GABRA2 gene, combined with the evidence for an effect of this gene on brain oscillations (Porjesz et al. 2002a) and anxiolysis (Low et al. 2000), draws these lines of evidence together.”
• Enhanced Learning and Memory and Altered GABAergic Synaptic Transmission in Mice Lacking the α5 Subunit of the GABAAReceptor (2002, background): “For example, it has been demonstrated that GABAA receptors containing an 1 subunit mediate sedative–muscle relaxant effects of benzodiazepines, whereas those containing an 2 or 3 subunit mediate the anxiolytic–anticonvulsant effects (Rudolph et al., 1999; Löw et al., 2000; McKernan et al., 2000).”
• Metabotropic glutamate receptors as novel targets for anxiety and stress disorders (2005, background): “By contrast, the anxiolytic properties of benzodiazepines have been attributed to their interaction with receptors containing the α 2 -receptor subtyp”
• Beyond classical benzodiazepines: Novel therapeutic potential of GABAA receptor subtypes (2011, background): “Histidine-to-arginine point mutations at a conserved residue in the α1, α2, α3 or α5 subunit abolish binding of diazepam, whereas the action of the physiological neurotransmitter GABA is preserve”
• GABAA Receptors: Subtypes Provide Diversity of Function and Pharmacology (2008, positive): “The anxiolytic activity of diazepam is mediated primarily by GABAA-Rs composed of a2bg2 subunits (Low et al., 2000), and, under conditions of high receptor occupancy, also by a3 GABAA-Rs (Dias et al.”
• Cortical inhibitory neurons and schizophrenia (2005, background): “Furthermore, as the anxiolytic effects of benzodiazepines seem to be mediated by α2 subunit-containing GABA A receptor”
• Molecular and neuronal substrates for general anaesthetics (2004, background): “and the anxiolytic-like action of diazepam by α2-containing GABA A receptor”
• The biology of fear- and anxiety-related behaviors (2002, background): “The anxiolytic action of diazepam was suppressed in mice with the α2(H101R) point mutation, but not in those with the α3(H126R) point mutation.(99) Heterozygous γ2-knockout mice (γ2+/-) have been generated (the homozygous mutation is not viable).”
• General anesthetic actions in vivo strongly attenuated by a point mutation in the GABAA receptor β3 subunit (2003, background): “For instance, whereas α1-containing GABAA receptors mediate the sedative and anterograde amnesic actions of diazepam (8, 9), its anxiolytic action is mediated by α2-containing GABAA receptors (10).”