GABAA Receptors: Subtypes Provide Diversity of Function and Pharmacology
By Richard W. Olsen, W. Sieghart. Neuropharmacology, 2008
1,025 citations recorded by the source corpus.
This mini-review attempts to update experimental evidence on the existence of GABA(A) receptor pharmacological subtypes and to produce a list of those native receptors that exist. GABA(A) receptors are chloride channels that mediate inhibitory neurotransmission. They are members of the Cys-loop pentameric ligand-gated ion channel (LGIC) superfamily and share structural and functional homology with other members of that family. They are assembled from a family of 19 homologous subunit gene products and form numerous receptor subtypes with properties that depend upon subunit composition, mostly hetero-oligomeric. These vary in their regulation and developmental expression, and importantly, in brain regional, cellular, and subcellular localization, and thus their role in brain circuits and behaviors. We propose several criteria for including a receptor hetero-oligomeric subtype candidate on a list of native subtypes, and a working GABA(A) receptor list. These criteria can be applied to all the members of the LGIC superfamily. The list is divided into three categories of native receptor subtypes: "Identified", "Existence with High Probability", and "Tentative", and currently includes 26 members, but will undoubtedly grow, with future information. This list was first presented by Olsen & Sieghart (in press).
Subfields: Cellular and Molecular Neuroscience, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/245da863cb2f31d3081e1216da068eec78450aae
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In Cellular and Molecular Neuroscience
In Molecular Biology
Citations in the corpus
- Extrasynaptic GABAA receptors: Their function in the CNS and implications for disease (2012, background): “The mitochondrial TSPO is also in CNS neurons where it may mediate autologous effects of neurosteroids on neuronal excitability in brain slices following benzodiazepine (Tokuda et al., 2010) or ethanol (Tokuda et al., 2011) administration.”