General anesthetic actions in vivo strongly attenuated by a point mutation in the GABAA receptor β3 subunit
By Rachel Jurd, Margarete Arrasa, Sachar Lambert, B. Drexler, R. Siegwart, F. Crestani, M. Zaugg, K. Vogt, B. Ledermann, B. Antkowiak and 1 more. The FASEB Journal, 2003
599 citations recorded by the source corpus.
Subfields: Cellular and Molecular Neuroscience, Cognitive Neuroscience, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/264ff429a7c80d96dbdcd4d12363854b5c1d5540
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In Cellular and Molecular Neuroscience
In Cognitive Neuroscience
In Molecular Biology
Citations in the corpus
- Alcoholism: a systems approach from molecular physiology to addictive behavior. (2009, background): “5 N265M: the in vivo action of general anesthetics is strongly attenuated by this point mutation (227).”
- International Union of Pharmacology. LXX. Subtypes of γ-Aminobutyric AcidA Receptors: Classification on the Basis of Subunit Composition, Pharmacology, and Function. Update (2008, background): “…effects of etomidate in the mouse knockin (Reynolds et al., 2003), whereas the (cid:7) 3 knockin N265M eliminates the immobilizing effect to a noxious stimulus of etomidate and suppresses loss of the righting reflex to this agent, typical of general anesthetics (Jurd et al., 2003).”
- GABAA Receptors: Subtypes Provide Diversity of Function and Pharmacology (2008, unknown): “The sensitivity of drugs towards the respective residues bM2-150 in b2- and b3-containing receptors led to the production of knockin mice which exhibited a reduced sensitivity to the sedative (b2N265S: Reynolds et al., 2003) and anesthetic actions of etomidate in vivo (b3N265M: Jurd et al., 2003).”
- General anaesthesia: from molecular targets to neuronal pathways of sleep and arousal (2008, unknown): “These studies are of particular interest because if a specific mutation that affects only anaesthetic modulation (and no other channel properties) is identified, it would be possible, by introducing such a 'silent' mutation into mice, to test the importance of the receptor to the in vivo anaesthet”