Enhanced Learning and Memory and Altered GABAergic Synaptic Transmission in Mice Lacking the α5 Subunit of the GABAAReceptor

By N. Collinson, F. Kuenzi, W. Jarolimek, K. Maubach, Rosa Cothliff, C. Sur, Alison J. Smith, F. Otu, O. Howell, J. Atack and 5 more. Journal of Neuroscience, 2002

640 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Cognitive Neuroscience, Neurology

View Paper: https://www.semanticscholar.org/paper/19b3074bbc302238d442c0540d2191d16a424965

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cellular and Molecular Neuroscience

1. Richard W. Olsen
2. W. Sieghart
3. István Módy
4. S. Brickley
5. G. Homanics
6. U. Rudolph

In Cognitive Neuroscience

1. U. Rudolph
2. Richard W. Olsen
3. István Módy
4. S. Brickley
5. W. Sieghart

In Neurology

1. W. Sieghart

Citations in the corpus

• Extrasynaptic GABAA receptors: Their function in the CNS and implications for disease (2012, background): “First, mice with a partial or full deficit of a5-GABAARs show improved performance in associative learning and memory tasks (Collinson et al., 2002; Crestani et al., 2002; Yee et al., 2004), with only a minimal deficit in memory for object location (Prut et al., 2010).”
• Synaptic and nonsynaptic localization of GABAA receptors containing the α5 subunit in the rat brain (2006, background): “Moreover, the 5 / mouse mutant has reduced tonic currents, while they show no change in the mIPSCs when compared with the control nonmutant mouse (Caraiscos et al., 2004).”
• GABAA Receptors: Subtypes Provide Diversity of Function and Pharmacology (2008, positive): “The a5bg2 receptors seem to influence learning and memory, shown by improved spatial memory in mice with knockout of a5 subunits (Collinson et al., 2002), and improved trace fear conditioning in the point-mutated a5 knock-in mouse (Crestani et al., 2002).”
• Compensatory alteration of inhibitory synaptic circuits in cerebellum and thalamus of γ‐aminobutyric acid type A receptor α1 subunit knockout mice (2006, background): “In contrast, deletion of the 3 or 5 subunits, which exhibit a limited expression pattern in the brain (Fritschy and Mohler, 1995), does not alter the expression of other subunits variants (Collinson et al., 2002; Fritschy et al., 1997; Yee et al., 2005), whereas, to our knowledge, no data are availa”
• Tonic Inhibitory Control of Dentate Gyrus Granule Cells by α5-Containing GABAA Receptors Reduces Memory Interference (2015, background): “Previous studies have shown that the reduction of tonic inhibition through global manipulations can enhance trace fear conditioning (Collinson et al., 2002; Crestani et al., 2002; Yee et al., 2004; Wiltgen et al., 2005; Moore et al., 2010).”
• General anesthetic actions in vivo strongly attenuated by a point mutation in the GABAA receptor β3 subunit (2003, background): “Mice lacking the α1 (40, 41), α5 ( 42 ), α6 (43, 44), β2 (40), β3 (45), δ (46), and γ2 (47) subunits of GABAA receptors have been generated and of these lines, the α6, δ, and β3 lines have been examined for alterations in general anesthetic responses.”