Autophagy and multidrug resistance in cancer

By Ying‐jie Li, Yu-he Lei, Nan Yao, Chen-Ran Wang, Nan Hu, W. Ye, Dong-Mei Zhang, Zhesheng Chen. Chinese journal of cancer, 2017

608 citations recorded by the source corpus.

Multidrug resistance (MDR) occurs frequently after long-term chemotherapy, resulting in refractory cancer and tumor recurrence. Therefore, combatting MDR is an important issue. Autophagy, a self-degradative system, universally arises during the treatment of sensitive and MDR cancer. Autophagy can be a double-edged sword for MDR tumors: it participates in the development of MDR and protects cancer cells from chemotherapeutics but can also kill MDR cancer cells in which apoptosis pathways are inactive. Autophagy induced by anticancer drugs could also activate apoptosis signaling pathways in MDR cells, facilitating MDR reversal. Therefore, research on the regulation of autophagy to combat MDR is expanding and is becoming increasingly important. We summarize advanced studies of autophagy in MDR tumors, including the variable role of autophagy in MDR cancer cells.

Subfields: Epidemiology, Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/f35b040ce80126f0b1f0c3280b8c2807d8e358bd

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In Molecular Biology

1. Yongqian Shu
2. Ke Wei
3. Xinming Jing
4. C. Shao
5. Fengming Yang
6. M. Xie
7. Hua Shen

Citations in the corpus

• Role of hypoxia in cancer therapy by regulating the tumor microenvironment (2019, background): “Besides apoptosis, the process of autophagy is widely recognized as a critical regulator of cellular viability [92].”