Loss of autophagy diminishes pancreatic beta cell mass and function with resultant hyperglycemia.

By H. Jung, Kun Wook Chung, Jeong Won Kim, Jin Woong Kim, M. Komatsu, Keiji Tanaka, Yen Hoang Nguyen, T. Kang, K. Yoon, Ji-Won Kim and 6 more. Cell Metabolism, 2008

666 citations recorded by the source corpus.

Subfields: Epidemiology, Pharmacology, Surgery

View Paper: https://www.semanticscholar.org/paper/196a6fa4abb0cac7bbb9c562bb6ea3a50a092b81

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Epidemiology

1. Beth Levine
2. Guido Kroemer
3. N. Mizushima
4. Alec C. Kimmelman
5. D. Rubinsztein
6. A. Cuervo
7. Guillermo Mariño
8. M. Komatsu

In Pharmacology

1. Guido Kroemer
2. Beth Levine
3. N. Mizushima
4. Alec C. Kimmelman
5. M. Komatsu
6. Guillermo Mariño
7. D. Rubinsztein
8. A. Cuervo

In Surgery

1. Beth Levine
2. Guido Kroemer
3. Guillermo Mariño
4. Alec C. Kimmelman
5. N. Mizushima
6. G. Hotamışlıgil
7. C. Hetz

Citations in the corpus

• Defective Hepatic Autophagy in Obesity Promotes ER Stress and Causes Insulin Resistance (2010, background): “Combined with the potential reported role in islet function and survival (Ebato et al., 2008; Jung et al., 2008), the data presented here indicate that autophagy may be a relevant mechanism for the two major pathological arms of type 2 diabetes: impaired insulin secretion and insulin sensitivity.”
• Biological Functions of Autophagy Genes: A Disease Perspective (2019, background): “…(liver or pancreas) deletion of ATG genes or TFEB gain more weight when fed a high-fat diet and have an increased propensity to develop systemic inflammation, diabetes, and hepatic steatosis (Fernández et al., 2017; Jung et al., 2008; Lim et al., 2014; Settembre et al., 2013a; Singh et al., 2009).”
• Autophagy in the Cellular Energetic Balance (2011, positive): “Autophagy can indirectly contribute to glucose metabolism by modulating pancreatic b-cell mass and function (Ebato et al., 2008; Jung et al., 2008).”
• Autophagy: Renovation of Cells and Tissues (2011, background): “Pancreas Constitutive suppression of autophagic activity in pancreatic b cells causes reduction in b cell mass, hypoinsulinemia, and the accumulation of ubiquitinated proteins, p62, and deformed organelles (i.e., mitochondria and ER) (Ebato et al., 2008; Jung et al., 2008).”
• Endoplasmic Reticulum Stress and the Inflammatory Basis of Metabolic Disease (2010, positive): “Two studies demonstrated that autophagy is essential for pancreatic islet function and survival and that a lack of autophagy leads to islet degeneration and reduced insulin secretion (Ebato et al., 2008; Jung et al., 2008).”
• Pancreatic cancers require autophagy for tumor growth. (2011, positive): “2D), consistent with the known role of constitutive autophagy in b -cell homeostasis (Jung et al. 2008).”
• Long live FOXO: unraveling the role of FOXO proteins in aging and longevity (2015, background): “As previously mentioned, decreased autophagy has been related to premature aging and age-related associated disorders (Hara et al., 2006; Komatsu et al., 2006; Jung et al., 2008; Pickford et al., 2008; Masiero et al., 2009; Lee et al., 2010).”
• Autophagy and aging. (2011, background): “…to high-fat diet-induced diabetes; this phenotype can be improved by feeding the antioxidant N-acetylcysteine Insulin-dependent diabetes Jung et al., 2008; Ebato et al., 2008; Wu et al., 2009 No cardiac phenotype in baseline conditions but enhanced susceptibility to acute pressure…”