The Role of Ventromedial Prefrontal Cortex in the Recovery of Extinguished Fear

By Gregory J. Quirk, G. Russo, Jill L. Barron, Kelimer Lebrón. Journal of Neuroscience, 2000

1,003 citations recorded by the source corpus.

Subfields: Behavioral Neuroscience, Cellular and Molecular Neuroscience, Cognitive Neuroscience

View Paper: https://www.semanticscholar.org/paper/0bf9fd4723cc2cc4eaccd24ba45efdb3c055305a

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Citations in the corpus

Medial prefrontal cortex determines how stressor controllability affects behavior and dorsal raphe nucleus (2005, background): “mPFCv lesions have proven to have no effect on the acquisition of conditioned fea”
Fear extinction and relapse: state of the art. (2013, background): “Interestingly, the available research supports a much more consistent role for the hippocampal-vmPFC network in extinction recall (e.g., 24 hours later) than during initial extinction learning (Milad & Quirk 2002, Quirk et al. 2000).”
Psychobiological mechanisms of resilience and vulnerability: implications for successful adaptation to extreme stress. (2004, background): “Destruction of the medial prefrontal cortex blocks recall of fear extinction (183, 184), indicating that the medial prefrontal cortex might store long-term extinction memory.”
Extinction learning in humans: role of the amygdala and vmPFC. (2004, background): “Further lesion studies (Quirk et al., 2000) demonstrated thatresponse in both acquisition and early extinction.”
Behavioral and neural analysis of extinction. (2002, background): “…with exposure to CS- US pairings are by far the best characterized, there is also found no difference between groups in extinction retention, whereas Quirk et al. (2000) reported increaseda small literature documenting cortical plasticity during extinction training (for a review, see Falls and…”
Dissociable roles of prelimbic and infralimbic cortices, ventral hippocampus, and basolateral amygdala in the expression and extinction of conditioned fear (2010, positive): “Impaired retrieval of extinction could result from impaired acquisition of extinction and/or impaired consolidation of extinction (Quirk et al., 2000).”
Prefrontal mechanisms in extinction of conditioned fear. (2006, neutral): “…that they may participate in long-term torage of extinction. onflicting Lesion Evidence on the Role of the mPFC n Extinction Although there is much physiological evidence in favor of a unctional role of mPFC in learning and expression of extinction, here also are conflicting lesion reports.”
Recall of fear extinction in humans activates the ventromedial prefrontal cortex and hippocampus in concert. (2007, background): “Rats with vmPFC lesions extinguish but show impaired extinction recall 24 hours later (Lebron et al. 2004; Quirk et al. 2000).”
Neurobiological Basis of Failure to Recall Extinction Memory in Posttraumatic Stress Disorder (2009, background): “the learned extinction memory after a delay (25).”
Rethinking Feelings: An fMRI Study of the Cognitive Regulation of Emotion (2002, background): “Some animal lesion studies indicate that medial lesions impair extinction (Morgan et al., 1995), others suggest that they do not (Gewirtz, Falls, & Davis, 1997), whereas others suggest that the impairments may be observed only during some phases of extinction ( Quirk, Russo, Barron, & Leborn, 2000 )”
Microstimulation reveals opposing influences of prelimbic and infralimbic cortex on the expression of conditioned fear. (2006, methodology): “Lesions restricted to IL impair recall of extinction (Quirk et al. 2000; Lebron et al. 2004), causing increased freezing at test.”