Prefrontal mechanisms in extinction of conditioned fear.

By Gregory J. Quirk, René Garcia, F. Gonzalez-Lima. Biological Psychiatry, 2006

681 citations recorded by the source corpus.

Subfields: Behavioral Neuroscience, Cellular and Molecular Neuroscience, Cognitive Neuroscience

View Paper: https://www.semanticscholar.org/paper/05282d5d6a1f13551d81c18ed9fb3602ee531df5

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In Behavioral Neuroscience

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Citations in the corpus

The Neurocircuitry of Fear, Stress, and Anxiety Disorders (2011, background): “Extinction learning or, more likely, the later recall of this learning involves the ventromedial prefrontal cortex (vmPFC) (Milad and Quirk, 2002; Morgan et al, 1993; Quirk et al, 2000, 2003, 2006) in rodents.”
Dissociable roles of prelimbic and infralimbic cortices, ventral hippocampus, and basolateral amygdala in the expression and extinction of conditioned fear (2010, neutral): “…in the ventral medial prefrontal cortex (vmPFC) is important for the retrieval of extinction memory (Morgan et al., 1993; Milad and Quirk, 2002; Quirk et al., 2006; Sotres-Bayon et al., 2006), and the hippocampus is thought to mediate the contextual gating of extinction (Corcoran et al., 2005;…”
Brain On Stress: Vulnerability and Plasticity of the Prefrontal Cortex Over the Life Course (2013, positive): “Moreover, fear extinction is known to involve the prefrontal cortex (Quirk et al., 2006), and adolescent rodents and humans show a deficit in fear extinction that is not present before or after the adolescent phase (Pattwell et al.”
Plastic Synaptic Networks of the Amygdala for the Acquisition, Expression, and Extinction of Conditioned Fear (2010, positive): “In contrast, the infralimbic component of the mPFC is critical for the consolidation and recall of extinction (387).”
Social learning of fear (2007, background): “More specifically, the ventral (infralimbic) region of the medial prefrontal cortex (MPFC) is critical to retention of extinction of conditioned fear responses in rat”
Don't fear ‘fear conditioning’: Methodological considerations for the design and analysis of studies on human fear acquisition, extinction, and return of fear (2017, positive): “…available today derived from animal experiments on the behaviour, neurobiology and pharmacology of the acquisition (Davis et al., 1993; LeDoux, 2000), extinction (Bouton et al., 2006a,b; Myers and Davis, 2002; Quirk et al., 2006), and return (Bouton, 2002; Vervliet et al., 2013b) of fear responses.”
Neural Mechanisms of Extinction Learning and Retrieval (2008, background): “for both IL bursting and consolidation of extinction (Burgos-Robles et al, 2007), suggesting that bursting may trigger calcium currents in IL necessary for stabilizing extinction memory (Quirk et al, 2006).”
Cognitive reappraisal of emotion: a meta-analysis of human neuroimaging studies. (2014, background): “…appear somewhat surprising, given the rich neuroscience literature demonstrating the involvement of vmPFC in fear extinction, reversal learning, and regulation of social behavior (Bechara et al. 2005; Quirk and Beer 2006; Quirk et al. 2006; Milad et al. 2007; Wager et al. 2007; Finger et al. 2008).”
Prefrontal control of fear: more than just extinction (2010, background): “Nonetheless, interest in the role of PFC in emotion re-emerged with the discovery that the medial PFC (mPFC) was necessary for extinction of conditioned fear [7,8].”
Psychedelics Promote Structural and Functional Neural Plasticity (2018, background): “Because the PFC is a key brain region involved in extinction learning (Quirk et al., 2006), and both ketamine and DMT have been shown to facilitate fear extinction (Cameron et al.”
Microstimulation reveals opposing influences of prelimbic and infralimbic cortex on the expression of conditioned fear. (2006, background): “…been considered a site of storage of conditioned fear memories, recent findings suggest that the medial prefrontal cortex (mPFC) regulates expression of amygdaladependent memories, especially following extinction (SotresBayon et al. 2004; Amat et al. 2005; Milad et al. 2005; Quirk et al. 2006).”
Social bonds and posttraumatic stress disorder. (2008, background): “…and ultimately avoidance and numbing (Cahill 1997, Cahill et al. 2003, Frewen & Lanius 2006, Kazui et al. 2000, Pitman & Delahanty 2005, Quirk et al. 2006, Rauch et al. 2006, Rothbaum & Davis 2003, Shin et al. 2006), and the resolution of fear and various other associated emotions is…”