Distinct endothelial phenotypes evoked by arterial waveforms derived from atherosclerosis-susceptible and -resistant regions of human vasculature.

By G. Dai, M. Kaazempur-Mofrad, S. Natarajan, Yuzhi Zhang, Saran Vaughn, B. Blackman, Roger D. Kamm, G. Garcı́a-Cardeña, M. Gimbrone. Proceedings of the National Academy of Sciences of the United States of America, 2004

706 citations recorded by the source corpus.

Subfields: Immunology, Molecular Biology, Surgery

View Paper: https://www.semanticscholar.org/paper/0ad260a4636d47efe5da47726c9c412b6aec35c9

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. Peter Libby
2. G. Hansson
3. Shu Chien
4. J. Chiu
5. P. Ridker
6. I. Tabas
7. V. Z. Rocha
8. Jongsoon Lee

In Molecular Biology

1. Peter Libby
2. G. Hansson
3. J. Chiu
4. Shu Chien
5. Christopher S. Chen
6. P. Ridker

In Surgery

1. Peter Libby
2. G. Hansson
3. Charles A. Taylor
4. C. Alberto Figueroa
5. Shu Chien
6. J. Chiu
7. I. Tabas
8. A. Tall

Citations in the corpus

• Effects of Disturbed Flow on Vascular Endothelium: Pathophysiological Basis and Clinical Perspectives (2011, methodology): “In contrast, exposure to laminar flow or shear stress with atheroprotective waveform increases the expression of sets of atheroprotective genes (50, 51, 60, 75, 115, 116, 201, 370, 652).”
• The immune response in atherosclerosis: a double-edged sword (2006, background): “Interestingly, exposing cultured endothelial cells to oscillatory shear stress that mimics arterial blood flow increases the expression of several leukocyte adhesion molecule”
• Mechanical control of stem cell differentiation (2008, background): “did not establish a direct role for shear flow in regulating endothelial cell differentiation, other studies have demonstrated that changes in shear flow is associated with widescale reprogramming of gene expression in endothelial cells (Dai et al., 2004; Garcia-Cardena et al., 2001), and has induct”
• Patient-specific Modeling of Cardiovascular Mechanics (2009, background): “Recently, Gimbrone’s lab at Harvard described phenotypic differences in endothelial cells exposed to different shear stress waveforms characterized using image-based modeling techniques in the carotid artery bifurcation (86).”
• Endothelial Cell Dysfunction and the Pathobiology of Atherosclerosis (2016, neutral): “focused on transcriptional regulators.(161,165,166) Among the transcription factors most responsive to hemodynamic stimuli, the zinc finger transcription factor, Kruppel-like factor 2 (KLF2), seemed to show the strongest differential upregulation by atheroprotective waveform stimulation.”
• Mechanotransduction and endothelial cell homeostasis: the wisdom of the cell. (2007, background): “(18) have shown by microarray studies that exposure of cultured ECs to a waveform simulating the wall shear stresses of distal internal carotid artery (atheroresistant) results in the upregulation of KLF2 compared with that simulating the carotid sinus (atherosusceptible).”
• Vascular Adaptation to Exercise in Humans: Role of Hemodynamic Stimuli. (2017, background): “Conversely, exposure of rat carotid arteries Page 17 of 108 to low levels of shear stress for 4 hrs promoted the upregulation of adhesion molecules such ICAM-1 and VCAM-1 (236).”
• Role of endothelial shear stress in the natural history of coronary atherosclerosis and vascular remodeling: molecular, cellular, and vascular behavior. (2007, background): “Chemoattractants (MCP-1) Upregulated (46,47,66)”
• The role of shear stress in the pathogenesis of atherosclerosis (2005, methodology): “They used 3D flow analysis based on actual aortic artery bifurcation geometries and blood flow profiles to characterize an athero-prone and an atheroprotective waveform, which were applied to the endothelial cells in culture to analyze gene expression using transcription profiling”