Patient-specific Modeling of Cardiovascular Mechanics

By Charles A. Taylor, C. Alberto Figueroa. Annual Review of Biomedical Engineering, 2009

470 citations recorded by the source corpus.

Advances in numerical methods and three-dimensional imaging techniques have enabled the quantification of cardiovascular mechanics in subject-specific anatomic and physiologic models. Patient-specific models are being used to guide cell culture and animal experiments and test hypotheses related to the role of biomechanical factors in vascular diseases. Furthermore, biomechanical models based on noninvasive medical imaging could provide invaluable data on the in vivo service environment where cardiovascular devices are employed and the effect of the devices on physiologic function. Finally, the patient-specific modeling has enabled an entirely new application of cardiovascular mechanics, namely predicting outcomes of alternate therapeutic interventions for individual patients. We will review methods to create anatomic and physiologic models, obtain properties, assign boundary conditions, and solve the equations governing blood flow and vessel wall dynamics. Applications of patient-specific models of cardiovascular mechanics will be presented followed by a discussion of the challenges and opportunities that lie ahead.

Subfields: Biomedical Engineering, Cardiology and Cardiovascular Medicine, Surgery

View Paper: https://www.semanticscholar.org/paper/5bea5e97f2d710ff16053541d1092fc407b66760

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In Biomedical Engineering

In Cardiology and Cardiovascular Medicine

In Surgery

Citations in the corpus

A review of predictive nonlinear theories for multiscale modeling of heterogeneous materials (2017, background): “For biological systems, magnetic resonance imaging (MRI) and diagnostic sonography (ultrasonography) are popular in Patient-specific Modeling [202].”
Pulse Wave Propagation in the Arterial Tree (2011, methodology): “…et al. (1971) or 0D lumped transition line network versions such as in Westerhof et al. (1969), to more complex 3D models based on approximate numerical solutions of the full set of equations of motion for fluid-structure interaction (see, e.g., Taylor & Figueroa 2009, van de Vosse et al. 2003).”
Computational fluid dynamics applied to cardiac computed tomography for noninvasive quantification of fractional flow reserve: scientific basis. (2013, methodology): “For realistic patient-specific models of the human coronary arteries, a numerical method must instead be used to approximate the governing equations and to obtain a solution for velocity and pressure at a finite number of points (28).”