Role of endothelial shear stress in the natural history of coronary atherosclerosis and vascular remodeling: molecular, cellular, and vascular behavior.

By Y. Chatzizisis, A. Coskun, M. Jonas, E. Edelman, C. Feldman, P. Stone. Journal of the American College of Cardiology, 2007

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Visualizing stromal cell dynamics in different tumor microenvironments by spinning disk confocal microscopy (2008, background): “INTRODUCTION Atherosclerotic lesions form at specific sites on blood vessels subject to disturbed blood flow, such as in the vicinity of branch points, the outer wall of bifurcations, and the inner wall of curvatures (DeBakey et al., 1985; Glagov et al., 1988; Ku et al., 1985; Chatzizisis et al., 20”
Endothelial Cell Dysfunction and the Pathobiology of Atherosclerosis (2016, neutral): “in an autonomous fashion, thus suggesting that local factors are important determinants of their pathobiology.(209) Using a”
Effects of Disturbed Flow on Vascular Endothelium: Pathophysiological Basis and Clinical Perspectives (2011, background): “There is increasing evidence that various hemodynamic forces, including fluid shear stress, can also influence the structure and function of ECs and modulate their expressions of pathophysiologically relevant genes (74, 87, 93, 125, 131, 153, 203, 211, 213, 230, 240, 279, 282, 337, 571, 625).”
Update on acute coronary syndromes: the pathologists' view. (2013, background): “Atherosclerosis is a systemic, lipid-driven immune-inflammatory disease of medium-sized and large arteries leading to multifocal plaque development, 14 predominantly at predilection sites characterized by low and oscillatory endothelial shear stress.(15,16) The disease begins to develop early in lif”