The immune response in atherosclerosis: a double-edged sword

By G. Hansson, Peter Libby. Nature reviews. Immunology, 2006

2,374 citations recorded by the source corpus.

Subfields: Epidemiology, Immunology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/2e0fe095643614c91cefa62c4cdb1d7b7bb4c4d8

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Citations in the corpus

Inflammation in Atherosclerosis: From Pathophysiology to Practice (2009, background): “The subject of several recent reviews, this section will highlight recent advances in this area.(3) (25) (26) Interacting with a special subset of mononuclear phagocytes specialized in antigen presentation known as dendritic cells (Figure 1), T lymphocytes encounter antigens and mount a cellular imm”
Ly-6Chi monocytes dominate hypercholesterolemia-associated monocytosis and give rise to macrophages in atheromata. (2007, background): “Although we did not describe a role for Ly-6Clo cells in atherosclerosis, future studies may determine whether this subset, as a possible precursor of dendritic cells (38), influences the adaptive arm of the immune system, particularly with respect to antigen presentation and lymphocyte activation, ”
The IL-33/ST2 pathway: therapeutic target and novel biomarker (2008, background): “CD4+ cells have been implicated in the pathogenesis of atherosclerotic vascular disease (reviewed in Ref”
Local proliferation dominates lesional macrophage accumulation in atherosclerosis (2013, background): “Its sequence can be summarized as follows: (1) hematopoietic stem cells proliferate in the bone marrow and spleen and give rise to monocytes11,36,37; (2) Monocytes circulate, infiltrate, and differentiate to macrophages5–7,13; (3) Lesional macrophages proliferate and locally augment their numbers in”
Endothelial Cell Dysfunction and the Pathobiology of Atherosclerosis (2016, neutral): “Various pathophysiologic stimuli of ECD (Table) soon became the focus of fruitful investigation by multiple groups, and the molecular manifestations of ECD began to be characterized in detail.(11,15,19,30,35)”
Obesity, inflammation, and atherosclerosis (2009, background): “Despite their relative paucity, T cells powerfully modulate the immune response in atherogenesis”
From endoplasmic-reticulum stress to the inflammatory response (2008, background): “But prolonged or chronic inflammation is detrimental and has an important role in the development of diseases such as arthritis, Alzheimer's disease, type 1 and type 2 diabetes and cardiovascular diseas”
Reactive Oxygen Species in Health and Disease (2012, background): “As Hansson and Libby elegantly described the immune response in atherosclerosis as “double edged sword” [25], the description seems to perfectly fit the ROS.”
ICAM-1 signaling in endothelial cells (2009, background): “Atherosclerosis is a progressive disease characterized by the accumulation of lipids and fibrous elements in large arteries [52], and it increasingly threatens human health worldwide [30].”
Interleukin-1β inhibition and the prevention of recurrent cardiovascular events: rationale and design of the Canakinumab Anti-inflammatory Thrombosis Outcomes Study (CANTOS). (2011, background): “aspects of atherosclerosis including early cell adhesion, lesion propagation, matrix and collagen degradation, smooth muscle proliferation, heightened platelet reactivity, and thrombosis.(1,2) For clinicians, translation of the inflammatory hypoth-”
Progress and challenges in translating the biology of atherosclerosis (2011, background): “Translation from mice to humans The discovery of T cells in human atheromata, and the subsequent identification of almost all cell types involved in innate and adaptive immunity in human plaques, raised the possibility that the immune system could participate in atherogenesi”