Mechanotransduction and endothelial cell homeostasis: the wisdom of the cell.

By Shu Chien. American Journal of Physiology. Heart and Circulatory Physiology, 2007

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How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

Effects of Disturbed Flow on Vascular Endothelium: Pathophysiological Basis and Clinical Perspectives (2011, methodology): “Vascular endothelial cells (ECs), which form the inner lining of blood vessel wall with direct exposure to blood flow, serve important homeostatic functions in response to various chemical and mechanical stimuli (87, 111, 125, 337, 485, 573).”
The blood-brain barrier: an engineering perspective (2013, background): “These stresses play an important role in regulating endothelial cell morphology and function, and in mediating a wide range of signaling and transport processes between the vascular system and surrounding tissue (Chien, 2007; Hahn and Schwartz, 2009; Johnson et al., 2011; Conway and Schwartz, 2012).”
Mechanotransduction at a distance: mechanically coupling the extracellular matrix with the nucleus (2009, background): “Application of a mechanical stimulus, such as fluid shear stress, to the cell surface activates mechanosensitive ion channels, heterotrimeric G proteins, protein kinases and other membrane-associated signal-transduction molecules; these trigger downstream signalling cascades that lead to force-depen”
Piezo1, a mechanically activated ion channel, is required for vascular development in mice (2014, background): “In response to fluid shear stress in vitro, endothelial cells change their gene expression profiles and can realign their cytoskeletal structure (35).”